Brain‐derived neurotrophic factor shows a protective effect and improves recovery of the ERG b‐wave response in light‐damage
We investigated the neuroprotective effects of brain‐derived neurotrophic factor (BDNF) and its influence on the functional recovery of the retina following light‐induced retinal damage by electroretinogram (ERG). Rats were exposed to constant fluorescent light for 2, 5, 7, or 14 days, then returned...
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| Veröffentlicht in: | Journal of neurochemistry 2003-10, Vol.87 (2), p.290-296 |
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| container_title | Journal of neurochemistry |
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| creator | Ikeda, Kazuhito Tanihara, Hidenobu Tatsuno, Tohru Noguchi, Hiroshi Nakayama, Chikao |
| description | We investigated the neuroprotective effects of brain‐derived neurotrophic factor (BDNF) and its influence on the functional recovery of the retina following light‐induced retinal damage by electroretinogram (ERG). Rats were exposed to constant fluorescent light for 2, 5, 7, or 14 days, then returned to a cyclic light environment for 14 days. The result indicated that BDNF had few effects on the a‐wave amplitude, but there was a statistically significant difference in the b‐wave amplitudes between BDNF‐treated and control eyes from day 0–14 of the recovery period following 2 days of light exposure (p |
| doi_str_mv | 10.1046/j.1471-4159.2003.01994.x |
| format | Article |
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Rats were exposed to constant fluorescent light for 2, 5, 7, or 14 days, then returned to a cyclic light environment for 14 days. The result indicated that BDNF had few effects on the a‐wave amplitude, but there was a statistically significant difference in the b‐wave amplitudes between BDNF‐treated and control eyes from day 0–14 of the recovery period following 2 days of light exposure (p < 0.05). Our findings suggest that BDNF not only protects the retinal neuronal function but also enhances the recovery from retinal light damage.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1046/j.1471-4159.2003.01994.x</identifier><identifier>PMID: 14511106</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Animals ; Biological and medical sciences ; Brain-Derived Neurotrophic Factor - administration & dosage ; Brain-Derived Neurotrophic Factor - pharmacology ; brain‐derived neurotrophic factor ; Drug Administration Routes ; electroretinogram ; Electroretinography - drug effects ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. Psychology ; Light - adverse effects ; Male ; neuroprotection ; Neuroprotective Agents - administration & dosage ; Neuroprotective Agents - pharmacology ; neurotrophins ; photoreceptor ; Rats ; Rats, Wistar ; Recovery of Function - drug effects ; Retina - drug effects ; Retina - pathology ; Retina - radiation effects ; retinal damage ; Treatment Outcome ; Vertebrates: nervous system and sense organs</subject><ispartof>Journal of neurochemistry, 2003-10, Vol.87 (2), p.290-296</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4264-a16b3929db259e45212f06205965283314ab3d1d8fcd291e549bd32a77dfcc873</citedby><cites>FETCH-LOGICAL-c4264-a16b3929db259e45212f06205965283314ab3d1d8fcd291e549bd32a77dfcc873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1471-4159.2003.01994.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1471-4159.2003.01994.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15209407$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14511106$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ikeda, Kazuhito</creatorcontrib><creatorcontrib>Tanihara, Hidenobu</creatorcontrib><creatorcontrib>Tatsuno, Tohru</creatorcontrib><creatorcontrib>Noguchi, Hiroshi</creatorcontrib><creatorcontrib>Nakayama, Chikao</creatorcontrib><title>Brain‐derived neurotrophic factor shows a protective effect and improves recovery of the ERG b‐wave response in light‐damage</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>We investigated the neuroprotective effects of brain‐derived neurotrophic factor (BDNF) and its influence on the functional recovery of the retina following light‐induced retinal damage by electroretinogram (ERG). Rats were exposed to constant fluorescent light for 2, 5, 7, or 14 days, then returned to a cyclic light environment for 14 days. The result indicated that BDNF had few effects on the a‐wave amplitude, but there was a statistically significant difference in the b‐wave amplitudes between BDNF‐treated and control eyes from day 0–14 of the recovery period following 2 days of light exposure (p < 0.05). Our findings suggest that BDNF not only protects the retinal neuronal function but also enhances the recovery from retinal light damage.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain-Derived Neurotrophic Factor - administration & dosage</subject><subject>Brain-Derived Neurotrophic Factor - pharmacology</subject><subject>brain‐derived neurotrophic factor</subject><subject>Drug Administration Routes</subject><subject>electroretinogram</subject><subject>Electroretinography - drug effects</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Light - adverse effects</subject><subject>Male</subject><subject>neuroprotection</subject><subject>Neuroprotective Agents - administration & dosage</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>neurotrophins</subject><subject>photoreceptor</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Recovery of Function - drug effects</subject><subject>Retina - drug effects</subject><subject>Retina - pathology</subject><subject>Retina - radiation effects</subject><subject>retinal damage</subject><subject>Treatment Outcome</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1uEzEQxy0EoqHwCsgXuO3i8dq78YEDRG0BVSAhOFtee9w42o9gb5rmhngCnpEnwUsieoTTjDy__3z4TwgFVgIT9atNCaKBQoBUJWesKhkoJcq7B2Txt_CQLBjjvKiY4GfkSUobxqAWNTwmZyAkALB6QX68jSYMv77_dBjDLTo64C6OUxy362CpN3YaI03rcZ-oodtcQTtljqL3OaNmcDT0-f0WE41oc4wHOno6rZFefL6ibW69N1kQMW3HISENA-3CzXqaZ5re3OBT8sibLuGzUzwnXy8vvqzeFdefrt6v3lwXVvBaFAbqtlJcuZZLhUJy4J7VnElVS76sKhCmrRy4pbeOK0ApVOsqbprGeWuXTXVOXh775nW_7TBNug_JYteZAcdd0o1smJKM_xMExfPHAsvg8gjaOKYU0ettDL2JBw1Mz0bpjZ790LMfejZK_zFK32Xp89OMXdujuxeenMnAixNgkjWdj2awId1zkjMl2HzV6yO3Dx0e_nsB_eHjas6q3yq4si4</recordid><startdate>200310</startdate><enddate>200310</enddate><creator>Ikeda, Kazuhito</creator><creator>Tanihara, Hidenobu</creator><creator>Tatsuno, Tohru</creator><creator>Noguchi, Hiroshi</creator><creator>Nakayama, Chikao</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200310</creationdate><title>Brain‐derived neurotrophic factor shows a protective effect and improves recovery of the ERG b‐wave response in light‐damage</title><author>Ikeda, Kazuhito ; Tanihara, Hidenobu ; Tatsuno, Tohru ; Noguchi, Hiroshi ; Nakayama, Chikao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4264-a16b3929db259e45212f06205965283314ab3d1d8fcd291e549bd32a77dfcc873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain-Derived Neurotrophic Factor - administration & dosage</topic><topic>Brain-Derived Neurotrophic Factor - pharmacology</topic><topic>brain‐derived neurotrophic factor</topic><topic>Drug Administration Routes</topic><topic>electroretinogram</topic><topic>Electroretinography - drug effects</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Light - adverse effects</topic><topic>Male</topic><topic>neuroprotection</topic><topic>Neuroprotective Agents - administration & dosage</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>neurotrophins</topic><topic>photoreceptor</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Recovery of Function - drug effects</topic><topic>Retina - drug effects</topic><topic>Retina - pathology</topic><topic>Retina - radiation effects</topic><topic>retinal damage</topic><topic>Treatment Outcome</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ikeda, Kazuhito</creatorcontrib><creatorcontrib>Tanihara, Hidenobu</creatorcontrib><creatorcontrib>Tatsuno, Tohru</creatorcontrib><creatorcontrib>Noguchi, Hiroshi</creatorcontrib><creatorcontrib>Nakayama, Chikao</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ikeda, Kazuhito</au><au>Tanihara, Hidenobu</au><au>Tatsuno, Tohru</au><au>Noguchi, Hiroshi</au><au>Nakayama, Chikao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain‐derived neurotrophic factor shows a protective effect and improves recovery of the ERG b‐wave response in light‐damage</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>2003-10</date><risdate>2003</risdate><volume>87</volume><issue>2</issue><spage>290</spage><epage>296</epage><pages>290-296</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>We investigated the neuroprotective effects of brain‐derived neurotrophic factor (BDNF) and its influence on the functional recovery of the retina following light‐induced retinal damage by electroretinogram (ERG). Rats were exposed to constant fluorescent light for 2, 5, 7, or 14 days, then returned to a cyclic light environment for 14 days. The result indicated that BDNF had few effects on the a‐wave amplitude, but there was a statistically significant difference in the b‐wave amplitudes between BDNF‐treated and control eyes from day 0–14 of the recovery period following 2 days of light exposure (p < 0.05). Our findings suggest that BDNF not only protects the retinal neuronal function but also enhances the recovery from retinal light damage.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>14511106</pmid><doi>10.1046/j.1471-4159.2003.01994.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Brain-Derived Neurotrophic Factor - administration & dosage Brain-Derived Neurotrophic Factor - pharmacology brain‐derived neurotrophic factor Drug Administration Routes electroretinogram Electroretinography - drug effects Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Light - adverse effects Male neuroprotection Neuroprotective Agents - administration & dosage Neuroprotective Agents - pharmacology neurotrophins photoreceptor Rats Rats, Wistar Recovery of Function - drug effects Retina - drug effects Retina - pathology Retina - radiation effects retinal damage Treatment Outcome Vertebrates: nervous system and sense organs |
| title | Brain‐derived neurotrophic factor shows a protective effect and improves recovery of the ERG b‐wave response in light‐damage |
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