Brain‐derived neurotrophic factor shows a protective effect and improves recovery of the ERG b‐wave response in light‐damage

We investigated the neuroprotective effects of brain‐derived neurotrophic factor (BDNF) and its influence on the functional recovery of the retina following light‐induced retinal damage by electroretinogram (ERG). Rats were exposed to constant fluorescent light for 2, 5, 7, or 14 days, then returned...

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Veröffentlicht in:	Journal of neurochemistry 2003-10, Vol.87 (2), p.290-296
Hauptverfasser:	Ikeda, Kazuhito, Tanihara, Hidenobu, Tatsuno, Tohru, Noguchi, Hiroshi, Nakayama, Chikao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain-Derived Neurotrophic Factor - administration & dosage Brain-Derived Neurotrophic Factor - pharmacology brain‐derived neurotrophic factor Drug Administration Routes electroretinogram Electroretinography - drug effects Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Light - adverse effects Male neuroprotection Neuroprotective Agents - administration & dosage Neuroprotective Agents - pharmacology neurotrophins photoreceptor Rats Rats, Wistar Recovery of Function - drug effects Retina - drug effects Retina - pathology Retina - radiation effects retinal damage Treatment Outcome Vertebrates: nervous system and sense organs
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Zusammenfassung:	We investigated the neuroprotective effects of brain‐derived neurotrophic factor (BDNF) and its influence on the functional recovery of the retina following light‐induced retinal damage by electroretinogram (ERG). Rats were exposed to constant fluorescent light for 2, 5, 7, or 14 days, then returned to a cyclic light environment for 14 days. The result indicated that BDNF had few effects on the a‐wave amplitude, but there was a statistically significant difference in the b‐wave amplitudes between BDNF‐treated and control eyes from day 0–14 of the recovery period following 2 days of light exposure (p
ISSN:	0022-3042 1471-4159
DOI:	10.1046/j.1471-4159.2003.01994.x