Association of two apolipoprotein A-I gene MspI polymorphisms with high density lipoprotein (HDL)-cholesterol levels and indices of obesity in selected healthy Chinese subjects and in patients with early-onset type 2 diabetes

Summary objective Previous studies have reported associations between two apolipoprotein A‐I (apoA‐I) gene MspI polymorphisms (G‐75A and C83T) and high density lipoprotein (HDL)‐cholesterol and/or apoA‐I levels, but have not investigated the relationship with obesity. methods We determined the distribution of these polymorphisms in 482 early‐onset (≤ 40 years) Type 2 Chinese diabetics and 167 Chinese selected healthy controls. results The −75A and 83T allele frequencies were similar in the diabetic and healthy subjects. In the healthy control subjects, HDL‐cholesterol levels were significantly higher in the AA homozygotes than in the GG/GA carriers (1·74 ± 0·58 vs. 1·45 ± 0·58 mmol/l, P