Theophylline treatment may adversely affect the anoxia-induced erythropoietic response without suppressing erythropoietin production

To investigate the influence of theophylline on erythropoiesis in chronic obstructive pulmonary disease (COPD) and explore the potential underlying mechanisms. We evaluated the haematological parameters and erythropoietin (EPO) values in 38 COPD patients, 18 of which had been treated with theophylli...

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Veröffentlicht in:European journal of clinical pharmacology 2003-09, Vol.59 (5-6), p.379-383
Hauptverfasser: TSANTES, Argirios E, TASSIOPOULOS, Stergios T, PAPADHIMITRIOU, Stefanos I, BONOVAS, Stefanos, POULAKIS, Nikolaos, VLACHOU, Athina, FILIOUSSI, Kalitsa, LOUKOPOULOS, Dimitrios
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Sprache:eng
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Zusammenfassung:To investigate the influence of theophylline on erythropoiesis in chronic obstructive pulmonary disease (COPD) and explore the potential underlying mechanisms. We evaluated the haematological parameters and erythropoietin (EPO) values in 38 COPD patients, 18 of which had been treated with theophylline (8 mg/kg daily) for at least 1 year, and the other 20 had never received this drug; 38 sex- and age-matched healthy volunteers served as controls. We further studied the development of BFU-E (bursts forming units of erythrocyte precursors) -derived colonies in semisolid methylcellulose cultures in blood samples from 7 patients randomly selected from both groups. In addition, we studied the effects of theophylline on the erythroid cell development by adding this agent to erythroid cell cultures from 6 healthy volunteers at various concentrations. Haemoglobin values were found to be significantly lower in COPD patients treated with theophylline than in those untreated ( P
ISSN:0031-6970
1432-1041
DOI:10.1007/s00228-003-0640-0