Recent advances in the genetics of schizophrenia

The high heritability of schizophrenia has stimulated much work aimed at identifying susceptibility genes using positional genetics. As a result, several strong and well-established linkages have emerged. Three of the best-supported regions are 6p24–22, 1q21–22 and 13q32–34 where single studies have...

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Veröffentlicht in:	Human molecular genetics 2003-10, Vol.12 (suppl-2), p.R125-R133
Hauptverfasser:	O'Donovan, Michael C., Williams, Nigel M., Owen, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carrier Proteins - genetics Catechol O-Methyltransferase - genetics Chromosome Mapping Classical genetics, quantitative genetics, hybrids Cloning, Molecular D-Amino-Acid Oxidase - genetics Dysbindin Dystrophin-Associated Proteins Fundamental and applied biological sciences. Psychology Genetic Linkage Genetics of eukaryotes. Biological and molecular evolution Human Humans Neuregulin-1 - genetics Proline Oxidase - genetics RGS Proteins - genetics Schizophrenia - genetics
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Beschreibung
Zusammenfassung:	The high heritability of schizophrenia has stimulated much work aimed at identifying susceptibility genes using positional genetics. As a result, several strong and well-established linkages have emerged. Three of the best-supported regions are 6p24–22, 1q21–22 and 13q32–34 where single studies have achieved genome-wide significance at P
ISSN:	0964-6906 1460-2083
DOI:	10.1093/hmg/ddg302