The effect of controlled daily blood loss on the haemoglobin concentration, erythrocyte count and reticulocyte count of male rats

The effect of controlled daily blood loss on the haemoglobin concentration, erythrocyte count and reticulocyte count of male rats

0.2, 0.6 or 1 ml of blood was removed from rats once daily on 17 consecutive days. Haemoglobin concentration and erythrocyte counts fell rapidly until day 7 or 9 and were refelected after day 2 by an increase in reticulocytes. From day 9 to 17 there was little further change and 14 days after the la...

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Veröffentlicht in:Toxicology letters 1981-04, Vol.8 (1), p.29-32
Hauptverfasser: Capel-Edwards, K., Wheeldon, Joan M., Mifsud, C.V.J.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Erythrocyte Count
Hemoglobins - analysis
Hemorrhage - blood
Male
Rats
Reticulocytes
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Zusammenfassung:0.2, 0.6 or 1 ml of blood was removed from rats once daily on 17 consecutive days. Haemoglobin concentration and erythrocyte counts fell rapidly until day 7 or 9 and were refelected after day 2 by an increase in reticulocytes. From day 9 to 17 there was little further change and 14 days after the last bleed the haematological results were within the normal range. The increase in haemoglobin production correlated well with the increase of reticulocyte numbers.
ISSN:0378-4274
1879-3169
DOI:10.1016/0378-4274(81)90133-8