Versican in epithelial ovarian cancer: Relation to hyaluronan, clinicopathologic factors and prognosis

Versican, a proteoglycan previously reported to increase in other malignant tumours, was studied immunohistochemically in 299 primary epithelial ovarian cancers, their 43 metastases and 6 normal ovaries to evaluate its prognostic value and relation to hyaluronan, another extracellular matrix molecul...

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Veröffentlicht in:	International journal of cancer 2003-11, Vol.107 (3), p.359-364
Hauptverfasser:	Voutilainen, Kirsi, Anttila, Maarit, Sillanpää, Sari, Tammi, Raija, Tammi, Markku, Saarikoski, Seppo, Kosma, Veli‐Matti
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Biological and medical sciences cell adhesion Chondroitin Sulfate Proteoglycans - analysis extracellular matrix Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Hyaluronic Acid - analysis Immunohistochemistry Lectins, C-Type Medical sciences Middle Aged Neoplasms, Glandular and Epithelial - chemistry Neoplasms, Glandular and Epithelial - mortality Neoplasms, Glandular and Epithelial - pathology Ovarian Neoplasms - chemistry Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology ovarian tumours Prognosis survival Survival Rate Tumors versican Versicans
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Zusammenfassung:	Versican, a proteoglycan previously reported to increase in other malignant tumours, was studied immunohistochemically in 299 primary epithelial ovarian cancers, their 43 metastases and 6 normal ovaries to evaluate its prognostic value and relation to hyaluronan, another extracellular matrix molecule increased in cancer and a binding partner of versican. The stainings were scored according to the area percentage of strong versican signal of total peri‐ and intratumoural stroma as low (
ISSN:	0020-7136 1097-0215
DOI:	10.1002/ijc.11423