Effect of Molecular Size of Pegylated Peptide on the Pharmacokinetics and Tumor Targeting in Lymphoma-Bearing Mice

Purpose: Rapid blood and body clearances have hampered effective tumor targeting by small molecules. We used branched poly(ethylene glycol) (pegylated) polymers ( M r 40,000, M r 70,000, M r 100,000, and M r 150,000) conjugated to tumor-specific and control peptides to assess the effect of both mole...

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