PRADIMICINS FS AND FB, NEW PRADIMICIN ANALOGS: DIRECTED PRODUCTION, STRUCTURES AND BIOLOGICAL ACTIVITIES
Exogenous addition of D-serine to Actinomadura spinosa AA0851 resulted in directed production of pradimicin FS, a new D-serine analog of pradimicin S, together with pradimicin FB. Pradimicin FS was produced in higher yields by derivation of ferrous sulfate-resistant strains from strain AA0851. Pradi...
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| Veröffentlicht in: | Journal of antibiotics 1993/03/25, Vol.46(3), pp.398-405 |
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| container_end_page | 405 |
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| container_issue | 3 |
| container_start_page | 398 |
| container_title | Journal of antibiotics |
| container_volume | 46 |
| creator | SAITOH, KYOICHIRO SUZUKI, KIYOSHI HIRANO, MINORU FURUMAI, TAMOTSU OKI, TOSHIKAZU |
| description | Exogenous addition of D-serine to Actinomadura spinosa AA0851 resulted in directed production of pradimicin FS, a new D-serine analog of pradimicin S, together with pradimicin FB. Pradimicin FS was produced in higher yields by derivation of ferrous sulfate-resistant strains from strain AA0851. Pradimicin FB, a minor product, was identified as deglucosylpradimicin FL. Pradimicin FS was equivalent to pradimicin S in syncytium formation inhibition activity and in vitro and in vivo antifungal activities. |
| doi_str_mv | 10.7164/antibiotics.46.398 |
| format | Article |
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Pradimicin FS was produced in higher yields by derivation of ferrous sulfate-resistant strains from strain AA0851. Pradimicin FB, a minor product, was identified as deglucosylpradimicin FL. Pradimicin FS was equivalent to pradimicin S in syncytium formation inhibition activity and in vitro and in vivo antifungal activities.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.46.398</identifier><identifier>PMID: 8478258</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Actinomycetaceae - chemistry ; Animals ; Anthracyclines ; Antibiotics, Antineoplastic - analysis ; Antibiotics, Antineoplastic - isolation & purification ; Antibiotics, Antineoplastic - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal Agents - analysis ; Antifungal Agents - isolation & purification ; Antifungal Agents - pharmacology ; Antiviral agents ; Biological and medical sciences ; Fermentation ; Medical sciences ; Mice ; Microbial Sensitivity Tests ; Pharmacology. 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Antibiot.</addtitle><description>Exogenous addition of D-serine to Actinomadura spinosa AA0851 resulted in directed production of pradimicin FS, a new D-serine analog of pradimicin S, together with pradimicin FB. Pradimicin FS was produced in higher yields by derivation of ferrous sulfate-resistant strains from strain AA0851. Pradimicin FB, a minor product, was identified as deglucosylpradimicin FL. Pradimicin FS was equivalent to pradimicin S in syncytium formation inhibition activity and in vitro and in vivo antifungal activities.</description><subject>Actinomycetaceae - chemistry</subject><subject>Animals</subject><subject>Anthracyclines</subject><subject>Antibiotics, Antineoplastic - analysis</subject><subject>Antibiotics, Antineoplastic - isolation & purification</subject><subject>Antibiotics, Antineoplastic - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal Agents - analysis</subject><subject>Antifungal Agents - isolation & purification</subject><subject>Antifungal Agents - pharmacology</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Fermentation</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal Agents - analysis</topic><topic>Antifungal Agents - isolation & purification</topic><topic>Antifungal Agents - pharmacology</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Fermentation</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacology. 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Antibiot.</addtitle><date>1993</date><risdate>1993</risdate><volume>46</volume><issue>3</issue><spage>398</spage><epage>405</epage><pages>398-405</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>Exogenous addition of D-serine to Actinomadura spinosa AA0851 resulted in directed production of pradimicin FS, a new D-serine analog of pradimicin S, together with pradimicin FB. Pradimicin FS was produced in higher yields by derivation of ferrous sulfate-resistant strains from strain AA0851. Pradimicin FB, a minor product, was identified as deglucosylpradimicin FL. Pradimicin FS was equivalent to pradimicin S in syncytium formation inhibition activity and in vitro and in vivo antifungal activities.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>8478258</pmid><doi>10.7164/antibiotics.46.398</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of Antibiotics, 1993/03/25, Vol.46(3), pp.398-405 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75693831 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Actinomycetaceae - chemistry Animals Anthracyclines Antibiotics, Antineoplastic - analysis Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Agents - analysis Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Antiviral agents Biological and medical sciences Fermentation Medical sciences Mice Microbial Sensitivity Tests Pharmacology. Drug treatments Structure-Activity Relationship |
| title | PRADIMICINS FS AND FB, NEW PRADIMICIN ANALOGS: DIRECTED PRODUCTION, STRUCTURES AND BIOLOGICAL ACTIVITIES |
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