PRADIMICINS FS AND FB, NEW PRADIMICIN ANALOGS: DIRECTED PRODUCTION, STRUCTURES AND BIOLOGICAL ACTIVITIES

Exogenous addition of D-serine to Actinomadura spinosa AA0851 resulted in directed production of pradimicin FS, a new D-serine analog of pradimicin S, together with pradimicin FB. Pradimicin FS was produced in higher yields by derivation of ferrous sulfate-resistant strains from strain AA0851. Pradi...

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Veröffentlicht in:	Journal of antibiotics 1993/03/25, Vol.46(3), pp.398-405
Hauptverfasser:	SAITOH, KYOICHIRO, SUZUKI, KIYOSHI, HIRANO, MINORU, FURUMAI, TAMOTSU, OKI, TOSHIKAZU
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycetaceae - chemistry Animals Anthracyclines Antibiotics, Antineoplastic - analysis Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Agents - analysis Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Antiviral agents Biological and medical sciences Fermentation Medical sciences Mice Microbial Sensitivity Tests Pharmacology. Drug treatments Structure-Activity Relationship
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Zusammenfassung:	Exogenous addition of D-serine to Actinomadura spinosa AA0851 resulted in directed production of pradimicin FS, a new D-serine analog of pradimicin S, together with pradimicin FB. Pradimicin FS was produced in higher yields by derivation of ferrous sulfate-resistant strains from strain AA0851. Pradimicin FB, a minor product, was identified as deglucosylpradimicin FL. Pradimicin FS was equivalent to pradimicin S in syncytium formation inhibition activity and in vitro and in vivo antifungal activities.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.46.398