Inhibition of neutral cholesteryl ester hydrolase by a naturally occurring cytosolic protein in macrophages

The soluble fraction from a number of macrophage cell lines has been shown to contain a protein(s) that inhibits neutral cholesteryl ester hydrolase. The inhibition is dependent on the concentration of soluble protein used, and the efficiency of the inhibitor can be influenced by the inclusion of ol...

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Veröffentlicht in:	FEBS letters 1993-04, Vol.321 (2), p.132-134
Hauptverfasser:	Shand, John H., Crilly, Peter J., West, David W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Atherosclerosis Biological and medical sciences Cell Line Cholesteryl ester hydrolase Cytosol - physiology Enzymes and enzyme inhibitors Female Fundamental and applied biological sciences. Psychology Hydrolases Inhibition Kinetics Lactation - metabolism Macrophage Macrophages - physiology Mammary Glands, Animal - enzymology Mice Microsomes - enzymology Oleic Acid Oleic Acids - pharmacology Proteins - isolation & purification Proteins - pharmacology Rats Rats, Wistar Sterol Esterase - antagonists & inhibitors
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Beschreibung
Zusammenfassung:	The soluble fraction from a number of macrophage cell lines has been shown to contain a protein(s) that inhibits neutral cholesteryl ester hydrolase. The inhibition is dependent on the concentration of soluble protein used, and the efficiency of the inhibitor can be influenced by the inclusion of oleate and an inhibitor of ACAT. It is suggested that the presence of this material indicates that the macrophage contains a means of negatively controlling the activity of the hydrolytic phase of the cholesterol/cholesteryl ester cycle.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(93)80093-A