Growth factor modulation of surface ganglioside expression in cloned neoplastic glia
Cloned neoplastic astrocytes from a human glioma-derived cell line (IPSB-18) were grown in fetal calf serum (FCS)-supplemented culture medium in the presence of three growth factors. Basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) but not platelet-derived growth factor (PDGF) in...
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| Veröffentlicht in: | Neuroscience letters 1993-01, Vol.149 (1), p.1-5 |
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| container_title | Neuroscience letters |
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| creator | Pilkington, Geoffrey J. Dunan, Julie R. Rogers, Joan P. Clarke, Tracey M. Knott, Johanna C.A. |
| description | Cloned neoplastic astrocytes from a human glioma-derived cell line (IPSB-18) were grown in fetal calf serum (FCS)-supplemented culture medium in the presence of three growth factors. Basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) but not platelet-derived growth factor (PDGF) induced an increase in the number of cells positive for the ganglioside-recognizing monoclonal antibody, A2B5. No such growth factor-mediated induction could be detected in cells maintained in plasma-derived serum (PDS)-supplemented medium. Small molecules, removed from PDS during dialysis, may, therefore, act synergistically with growth factors in the control of ganglioside synthesis. |
| doi_str_mv | 10.1016/0304-3940(93)90332-F |
| format | Article |
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Basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) but not platelet-derived growth factor (PDGF) induced an increase in the number of cells positive for the ganglioside-recognizing monoclonal antibody, A2B5. No such growth factor-mediated induction could be detected in cells maintained in plasma-derived serum (PDS)-supplemented medium. Small molecules, removed from PDS during dialysis, may, therefore, act synergistically with growth factors in the control of ganglioside synthesis.</description><subject>Astrocytes - drug effects</subject><subject>Astrocytes - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell coat. Cell surface</subject><subject>Cell structures and functions</subject><subject>Epidermal Growth Factor - pharmacology</subject><subject>Fibroblast Growth Factor 2 - pharmacology</subject><subject>Fluorescent Antibody Technique</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglioside</subject><subject>Gangliosides - metabolism</subject><subject>Glia</subject><subject>Glioma - metabolism</subject><subject>Glioma - pathology</subject><subject>Growth factor</subject><subject>Histocytochemistry</subject><subject>Humans</subject><subject>Molecular and cellular biology</subject><subject>Neoplasm</subject><subject>Platelet-Derived Growth Factor - pharmacology</subject><subject>Tumor Cells, Cultured</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFq3DAQhkVpSDbbvkELOpSQHpxKlmRJl0AI2TQQyCU5i7E0TlW81kay2-bt480ue-xpYP5vhp-PkC-cXXDGmx9MMFkJK9m5Fd8tE6KuVh_IghtdV9rq-iNZHJATclrKb8aY4koek2MjGysauyCPtzn9HX_RDvyYMl2nMPUwxjTQ1NEy5XmP9BmG5z6mEgNS_LfJWMqWiAP1fRow0AHTpocyRk9nED6Row76gp_3c0meVjeP1z-r-4fbu-ur-8pLVY-VsUZyKbRsOVghoG0N7wJTxga0thGgoAmtl7pmKgCzDAw0DRj0XIgWW7EkZ7u_m5xeJiyjW8fise9hLjQVp1WjtZrhJZE70OdUSsbObXJcQ351nLmtTLc15bamnBXuXaZbzWdf9_-ndo3hcLS3N-ff9jkUD32XYfCxHDAptWK1mbHLHYaziz8Rsys-4uAxxIx-dCHF__d4A-bJkPw</recordid><startdate>19930104</startdate><enddate>19930104</enddate><creator>Pilkington, Geoffrey J.</creator><creator>Dunan, Julie R.</creator><creator>Rogers, Joan P.</creator><creator>Clarke, Tracey M.</creator><creator>Knott, Johanna C.A.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930104</creationdate><title>Growth factor modulation of surface ganglioside expression in cloned neoplastic glia</title><author>Pilkington, Geoffrey J. ; Dunan, Julie R. ; Rogers, Joan P. ; Clarke, Tracey M. ; Knott, Johanna C.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-898414374b1a933abb81fd0589de9963a5a6dbc47205da090a8a66a8ec133beb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Astrocytes - drug effects</topic><topic>Astrocytes - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell coat. Cell surface</topic><topic>Cell structures and functions</topic><topic>Epidermal Growth Factor - pharmacology</topic><topic>Fibroblast Growth Factor 2 - pharmacology</topic><topic>Fluorescent Antibody Technique</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglioside</topic><topic>Gangliosides - metabolism</topic><topic>Glia</topic><topic>Glioma - metabolism</topic><topic>Glioma - pathology</topic><topic>Growth factor</topic><topic>Histocytochemistry</topic><topic>Humans</topic><topic>Molecular and cellular biology</topic><topic>Neoplasm</topic><topic>Platelet-Derived Growth Factor - pharmacology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pilkington, Geoffrey J.</creatorcontrib><creatorcontrib>Dunan, Julie R.</creatorcontrib><creatorcontrib>Rogers, Joan P.</creatorcontrib><creatorcontrib>Clarke, Tracey M.</creatorcontrib><creatorcontrib>Knott, Johanna C.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pilkington, Geoffrey J.</au><au>Dunan, Julie R.</au><au>Rogers, Joan P.</au><au>Clarke, Tracey M.</au><au>Knott, Johanna C.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth factor modulation of surface ganglioside expression in cloned neoplastic glia</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1993-01-04</date><risdate>1993</risdate><volume>149</volume><issue>1</issue><spage>1</spage><epage>5</epage><pages>1-5</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Cloned neoplastic astrocytes from a human glioma-derived cell line (IPSB-18) were grown in fetal calf serum (FCS)-supplemented culture medium in the presence of three growth factors. Basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) but not platelet-derived growth factor (PDGF) induced an increase in the number of cells positive for the ganglioside-recognizing monoclonal antibody, A2B5. No such growth factor-mediated induction could be detected in cells maintained in plasma-derived serum (PDS)-supplemented medium. Small molecules, removed from PDS during dialysis, may, therefore, act synergistically with growth factors in the control of ganglioside synthesis.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8469369</pmid><doi>10.1016/0304-3940(93)90332-F</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1993-01, Vol.149 (1), p.1-5 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Astrocytes - drug effects Astrocytes - metabolism Biological and medical sciences Cell coat. Cell surface Cell structures and functions Epidermal Growth Factor - pharmacology Fibroblast Growth Factor 2 - pharmacology Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Ganglioside Gangliosides - metabolism Glia Glioma - metabolism Glioma - pathology Growth factor Histocytochemistry Humans Molecular and cellular biology Neoplasm Platelet-Derived Growth Factor - pharmacology Tumor Cells, Cultured |
| title | Growth factor modulation of surface ganglioside expression in cloned neoplastic glia |
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