Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression

The authors measured CSF concentrations of corticotropin-releasing hormone (CRH) and arginine vasopressin in nine depressed patients before and after fluoxetine treatment. They found significant decreases in CSF CRH, CSF arginine vasopressin, and Hamilton depression ratings. Thus, the therapeutic ef...

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Veröffentlicht in:	The American journal of psychiatry 1993-04, Vol.150 (4), p.656-657
Hauptverfasser:	DE BELLIS, M. D, GOLD, P. W, GERACIOTI, T. D, LISTWAK, S. J, KLING, M. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Arginine Vasopressin - cerebrospinal fluid Biological and medical sciences Brain Corticotropin-Releasing Hormone - cerebrospinal fluid Depression, Chemical Depressive Disorder - cerebrospinal fluid Depressive Disorder - drug therapy Depressive Disorder - psychology Drug therapy Female Fluoxetine - pharmacology Fluoxetine - therapeutic use Hormones Humans Male Medical research Medical sciences Mental depression Neuropharmacology Pharmacology. Drug treatments Psychiatric Status Rating Scales Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology
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Zusammenfassung:	The authors measured CSF concentrations of corticotropin-releasing hormone (CRH) and arginine vasopressin in nine depressed patients before and after fluoxetine treatment. They found significant decreases in CSF CRH, CSF arginine vasopressin, and Hamilton depression ratings. Thus, the therapeutic effect of this serotonin-uptake inhibitor may be related to diminution of these arousal-promoting neuropeptides.
ISSN:	0002-953X 1535-7228
DOI:	10.1176/ajp.150.4.656