Studies on lipid peroxidation in rat liver by copper deficiency

1. 1. Copper deficiency in rats results in a 2-fold increase in the level of lipid hydroperoxides in liver mitochondria and microsomes. 2. 2. The specific activity of cupro-zinc Superoxide dismutase decreases up to 30% while that of the mangano-enzyme is not changed. 3. 3. Glutathione peroxidase act...

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Veröffentlicht in:	International journal of biochemistry 1981, Vol.13 (4), p.489-493
Hauptverfasser:	Balevska, Penka S., Russanov, Elevter M., Kassabova, Todorka A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catalase - metabolism Copper - deficiency Copper - pharmacology Diet Glutathione Peroxidase - metabolism Lipid Peroxides - metabolism Male Manganese - pharmacology Microsomes, Liver - enzymology Mitochondria, Liver - enzymology Rats Superoxide Dismutase - metabolism Zinc - pharmacology
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Zusammenfassung:	1. 1. Copper deficiency in rats results in a 2-fold increase in the level of lipid hydroperoxides in liver mitochondria and microsomes. 2. 2. The specific activity of cupro-zinc Superoxide dismutase decreases up to 30% while that of the mangano-enzyme is not changed. 3. 3. Glutathione peroxidase activity as well as catalase activity are suppressed in both cytosol and mitochondrial fractions from copper-deficient rat liver.
ISSN:	0020-711X
DOI:	10.1016/0020-711X(81)90122-1