Pharmacokinetics and Bioavailability of Hydromorphone Following Intravenous and Oral Administration to Human Subjects

Pharmacokinetics and Bioavailability of Hydromorphone Following Intravenous and Oral Administration to Human Subjects

: In a relatively small pilot study, the half‐life of elimination of hydromorphone in six subjects was 2.64 ± 0.88 hours and the drug had a high volume of distribution, 1.22 1./kg. In addition, the drug was rapidly but incompletely absorbed after oral administration. An equation to predict the plasm...

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Veröffentlicht in:Journal of clinical pharmacology 1981-04, Vol.21 (4), p.152-156
Hauptverfasser: VALLNER, J. J., STEWART, J. T., KOTZAN, J. A., KIRSTEN, E.B., HONIGBERG, I. L.
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Adult
Biological Availability
Half-Life
Humans
Hydromorphone - administration & dosage
Hydromorphone - metabolism
Injections, Intravenous
Kinetics
Male
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Beschreibung
Zusammenfassung:: In a relatively small pilot study, the half‐life of elimination of hydromorphone in six subjects was 2.64 ± 0.88 hours and the drug had a high volume of distribution, 1.22 1./kg. In addition, the drug was rapidly but incompletely absorbed after oral administration. An equation to predict the plasma concentration of hydromorphone on oral administration was developed from the data of these six subjects.
ISSN:0091-2700
1552-4604
DOI:10.1002/j.1552-4604.1981.tb05693.x