Silent cerebral infarction is associated with the development and progression of nephropathy in patients with type 2 diabetes

Chronic kidney disease (CKD) is an important risk factor for cardiovascular disease in patients with diabetes. The relationship between renal manifestations of CKD (albuminuria and decreased glomerular filtration rate) and silent cerebral infarction (SCI) has attracted attention; however, most studi...

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Veröffentlicht in:	Hypertension research 2010-10, Vol.33 (10), p.1000-1003
Hauptverfasser:	Bouchi, Ryotaro, Babazono, Tetsuya, Yoshida, Naoshi, Nyumura, Izumi, Toya, Kiwako, Hayashi, Toshihide, Hanai, Ko, Tanaka, Nobue, Ishii, Akiko, Iwamoto, Yasuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	692/420 692/699/1585/2759/1419 692/699/2743/137/773 692/699/75/593/1370 Adult Aged Aged, 80 and over Albuminuria - physiopathology Cerebral Infarction - complications Cerebral Infarction - physiopathology Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - physiopathology Diabetic Nephropathies - epidemiology Diabetic Nephropathies - etiology Diabetic Nephropathies - physiopathology Disease Progression Female Geriatrics/Gerontology Glomerular Filtration Rate - physiology Health Promotion and Disease Prevention Humans Internal Medicine Japan Kaplan-Meier Estimate Male Medicine Medicine & Public Health Middle Aged Obstetrics/Perinatology/Midwifery original-article Predictive Value of Tests Proportional Hazards Models Public Health Retrospective Studies Risk Factors
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Beschreibung
Zusammenfassung:	Chronic kidney disease (CKD) is an important risk factor for cardiovascular disease in patients with diabetes. The relationship between renal manifestations of CKD (albuminuria and decreased glomerular filtration rate) and silent cerebral infarction (SCI) has attracted attention; however, most studies examined the effects of components of CKD on prevalence of SCI. We sought to assess the relationship between SCI and the development and progression of nephropathy in type 2 diabetic patients. We studied 366 type 2 diabetic patients with normoalbuminuria (urinary albumin-to-creatinine ratio [ACR]
ISSN:	0916-9636 1348-4214
DOI:	10.1038/hr.2010.122