Prenatal inflammation impairs adult neurogenesis and memory related behavior through persistent hippocampal TGFβ1 downregulation

Research highlights ► Prenatal LPS administration decreases adult neurogenesis in the dentate gyrus (DG). ► Prenatal LPS treatment induces persistent microglial activation in the adult DG. ► Prenatal LPS causes specific TGFβ1 downregulation in the adult hippocampus. ► Prenatal LPS impairs adult perf...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2010-11, Vol.24 (8), p.1301-1309
Hauptverfasser:	Graciarena, Mariana, Depino, Amaicha M, Pitossi, Fernando J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Allergy and Immunology Animals Antimetabolites Behavior, Animal - physiology beta-Galactosidase - biosynthesis beta-Galactosidase - genetics Bromodeoxyuridine Cell Proliferation Cytokines - biosynthesis Down-Regulation - physiology Female Genetic Vectors Hippocampus - cytology Hippocampus - physiology Lipopolysaccharides - pharmacology Macrophage Activation - physiology Maternal Behavior Memory - physiology Microglia - physiology Neurogenesis - physiology Pregnancy Prenatal Exposure Delayed Effects - pathology Prenatal Exposure Delayed Effects - psychology Psychiatry Rats Rats, Wistar Recognition (Psychology) - physiology RNA - biosynthesis RNA - genetics RNA - isolation & purification Transforming Growth Factor beta1 - biosynthesis Transforming Growth Factor beta1 - genetics
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Beschreibung
Zusammenfassung:	Research highlights ► Prenatal LPS administration decreases adult neurogenesis in the dentate gyrus (DG). ► Prenatal LPS treatment induces persistent microglial activation in the adult DG. ► Prenatal LPS causes specific TGFβ1 downregulation in the adult hippocampus. ► Prenatal LPS impairs adult performance in the Novel Object Recognition (NOR) test. ► Hippocampal TGFβ1 overexpression restores levels of adult neurogenesis and NOR performance.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2010.06.005