The "trap" hypothesis of venous ulceration

The pathogenesis of venous ulceration is unknown. We propose that macromolecules leaking into the dermis as a result of venous hypertension bind to or "trap" growth factors and matrix material, which then become unavailable for tissue repair and for the maintenance of tissue integrity.

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Bibliographische Detailangaben
Veröffentlicht in:	The Lancet (British edition) 1993-04, Vol.341 (8851), p.1006-1008
Hauptverfasser:	Falanga, Vincent, Eaglstein, WilliamH
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Macroglobulins - metabolism Biological and medical sciences Blood vessels Dermatology Fibrin - metabolism Fibrinogen - metabolism Growth factors Growth Substances - metabolism Humans Hypertension Macromolecular Substances Medical disorders Medical research Medical sciences Models, Biological Varicose Ulcer - etiology Vascular disorders of the skin
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Beschreibung
Zusammenfassung:	The pathogenesis of venous ulceration is unknown. We propose that macromolecules leaking into the dermis as a result of venous hypertension bind to or "trap" growth factors and matrix material, which then become unavailable for tissue repair and for the maintenance of tissue integrity.
ISSN:	0140-6736 1474-547X
DOI:	10.1016/0140-6736(93)91085-Z