Photoisomerized Bilirubin in Blood from Infants Receiving Phototherapy
A pigment different from (Z,Z)bilirubin-IXα was detected by fluorometric methods in blood specimens from new-born infants undergoing blue-light therapy for unconjugated hyperbilirubinemia; it was not detected in specimens from infants not under therapy. The phototherapy-associated pigment has fluore...
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Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1981-03, Vol.78 (3), p.1882-1886 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A pigment different from (Z,Z)bilirubin-IXα was detected by fluorometric methods in blood specimens from new-born infants undergoing blue-light therapy for unconjugated hyperbilirubinemia; it was not detected in specimens from infants not under therapy. The phototherapy-associated pigment has fluorescence, solubility, and photochemical properties that are identical to those exhibited by what are thought to be configurational (Z → E) isomers of bilirubin. It is concluded that isomerized bilirubin in the blood of neonates under phototherapy can reach as high as 15% of the total. |
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ISSN: | 0027-8424 1091-6490 |
DOI: | 10.1073/pnas.78.3.1882 |