Immunohistochemical Staining for CA-125 in Fallopian Tube Carcinomas

From 1981-1991, 15 patients with primary fallopian tube carcinomas were treated at the University of Kentucky Medical Center. Immunohistochemical staining for CA-125 was performed on tumor specimens from all cases. Thirteen tumors (87%) stained positively for CA-125. Antigen staining was most intens...

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Veröffentlicht in:	Gynecologic oncology 1993-03, Vol.48 (3), p.360-363
Hauptverfasser:	Puls, L.E., Davey, D.D., DePriest, P.D., Gallion, H.H., van Nageli, J.R., Hunter, J.E., Pavlik, E.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - diagnosis Adenocarcinoma - immunology Adenocarcinoma - pathology Adult Aged Antigens, Tumor-Associated, Carbohydrate - analysis Antigens, Tumor-Associated, Carbohydrate - blood Biological and medical sciences Fallopian Tube Neoplasms - diagnosis Fallopian Tube Neoplasms - immunology Fallopian Tube Neoplasms - pathology Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Medical sciences Middle Aged Neoplasm Staging Tumors
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Zusammenfassung:	From 1981-1991, 15 patients with primary fallopian tube carcinomas were treated at the University of Kentucky Medical Center. Immunohistochemical staining for CA-125 was performed on tumor specimens from all cases. Thirteen tumors (87%) stained positively for CA-125. Antigen staining was most intense in the apical portions of carcinoma cells. Serum CA-125 levels were measured in 5 patients and were elevated in 4 (80%). There was a positive correlation between tumor and serum antigen expression in these cases. Serum CA-125 levels accurately reflected disease status in the patients studied. These data suggest that CA-125 is a useful marker in patients with fallopian tube carcinoma. Immunohistochemical localization of CA-125 in tumor tissue should predict which patients will benefit most from serial antigen determinations.
ISSN:	0090-8258 1095-6859
DOI:	10.1006/gyno.1993.1063