Can pretreatment computed tomography findings predict local control in T3 squamous cell carcinoma of the glottic larynx treated with radiotherapy alone?
Purpose : To determine if pretreatment computed tomography findings can predict local control in T3 squamous cell carcinoma of the glottic larynx treated with radiotherapy alone. Methods and Materials : Twenty-nine patients with previously untreated T3 squamous cell carcinoma of the glottic larynx w...
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Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 1993-03, Vol.25 (4), p.683-687 |
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Zusammenfassung: | Purpose
: To determine if pretreatment computed tomography findings can predict local control in T3 squamous cell carcinoma of the glottic larynx treated with radiotherapy alone.
Methods and Materials
: Twenty-nine patients with previously untreated T3 squamous cell carcinoma of the glottic larynx were treated for cure with radiotherapy alone; all had a minimum 2-year follow-up. High-quality pretreatment computed tomography scans were retrospectively reviewed by a single head and neck radiologist for tumor involvement of various anatomic subsites within the larynx, and total tumor volumes were calculated for 18 of the most recent patients using a computer digitizer. A tumor score was calculated and assigned to each primary lesion depending on the extent of laryngeal spread.
Results
: A significant decrease in the local control rate was observed for cancers involving the face of the arytenoid (11 of 20 [55%] vs. 9 of 9 [100%];
p = .02), or the paraglottic space at the false vocal cord level (7 of 16 [44%] vs. 13 of 13 [100%];
p ≠ < .01). Tumors assigned a high tumor score (6, 7, or 8) had a significantly decreased rate of local control with radiation therapy when compared with tumors assigned a low tumor score (≤ 5): 1 of 7 (14%) vs. 19 of 22 (86%) (
p = .01). Total tumor volume also significantly correlated with the rate of tumor control. For tumors measuring 3.5 cm
3 or less, local control was achieved in 11 of 12 patients (92%), whereas for tumors greater than 3.5 cm
3, local control was achieved in 2 of 6 patients (33%) (
p = .02).
Conclusion
: Pretreatment computed tomography scans can contribute significantly to the treatment decision for patients with T3 glottic carcinoma and can define a subset of patients with an excellent chance of being cured with preservation of a functional larynx after treatment with radiotherapy alone. |
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ISSN: | 0360-3016 1879-355X |
DOI: | 10.1016/0360-3016(93)90016-O |