Membrane Fusion through Point Defects in Bilayers

Membrane Fusion through Point Defects in Bilayers

Fusion between bilayers of mixed egg phosphatidylcholine and soybean phosphatidylethanolamine was induced by freezing and thawing. Contact points between bilayers were observed by freeze fracture electron microscopy, and isotropic molecular motional averaging was detected by phosphorus-31 nuclear ma...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1981-05, Vol.212 (4497), p.921-923
Hauptverfasser: Hui, S. W., Stewart, T. P., Boni, L. T., Yeagle, P. L.
Format: Artikel
Sprache:eng
Schlagworte:
Ascites
Cell lines
Cell membranes
Dehydration
Freeze Fracturing
Lipid Bilayers
Lipids
Lymphocytes
Membranes (Biology)
Membranes - physiology
Models, Biological
Molecules
Nuclear magnetic resonance
Phosphatidylcholines
Phosphatidylethanolamines
Point defects
Tumors
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Beschreibung
Zusammenfassung:Fusion between bilayers of mixed egg phosphatidylcholine and soybean phosphatidylethanolamine was induced by freezing and thawing. Contact points between bilayers were observed by freeze fracture electron microscopy, and isotropic molecular motional averaging was detected by phosphorus-31 nuclear magnetic resonance under fusion conditions. A molecular model of point defect structure is proposed as an intermediate stage of fusion.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7233185