Tumor Detection with 1-Aminocyclopentane and 1-Aminocyclobutane C-11-Carboxylic Acid Using Positron Emission Computerized Tomography

Eight patients with proven or suspected neoplastic lesions were examined with 1-aminocyclobutane C-11-carboxylic acid and 1-aminocyclopentane C-11-carboxylic acid using positron emission computed tomography. The results of this comparative study have shown that both of these unnatural amino acids ha...

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Veröffentlicht in:	Clin. Nucl. Med.; (United States) 1981-06, Vol.6 (6), p.249-252
Hauptverfasser:	HÜBNER, KARL F, KRAUSS, STEPHEN, WASHBURN, LEE C, GIBBS, WILLIAM D, HOLLOWAY, ELIZABETH C
Format:	Artikel
Sprache:	eng
Schlagworte:	550601 - Medicine- Unsealed Radionuclides in Diagnostics 550901 - Pathology- Tracer Techniques 560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987) AFFINITY ALKANES Amino Acids - metabolism Amino Acids, Cyclic ANIMAL CELLS BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-PLUS DECAY RADIOISOTOPES BIOLOGICAL LOCALIZATION CARBON 11 CARBON ISOTOPES Carbon Radioisotopes CARBOXYLIC ACIDS COMPUTERIZED TOMOGRAPHY CYCLOALKANES Cycloleucine - metabolism DIAGNOSIS DIAGNOSTIC TECHNIQUES DIAGNOSTIC USES DISEASES EMISSION COMPUTED TOMOGRAPHY EVEN-ODD NUCLEI Humans HYDROCARBONS ISOTOPES LABELLED COMPOUNDS LIGHT NUCLEI METABOLISM MINUTES LIVING RADIOISOTOPES NEOPLASMS Neoplasms - diagnostic imaging NUCLEI ORGANIC ACIDS ORGANIC COMPOUNDS PATHOLOGY PATIENTS POSITRON COMPUTED TOMOGRAPHY RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE RADIONUCLIDE KINETICS TOMOGRAPHY Tomography, Emission-Computed - methods TUMOR CELLS UPTAKE USES
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Zusammenfassung:	Eight patients with proven or suspected neoplastic lesions were examined with 1-aminocyclobutane C-11-carboxylic acid and 1-aminocyclopentane C-11-carboxylic acid using positron emission computed tomography. The results of this comparative study have shown that both of these unnatural amino acids have a high affinity for malignant tumors. The potential of nonmetabolizable C-11-labeled amino acids as noninvasive indicators of metabolic tumor activity is demonstrated and discussed.
ISSN:	0363-9762 1536-0229
DOI:	10.1097/00003072-198106000-00004