A Rapid and Specific Method for Measuring Chloramphenicol Degradation in Aqueous Solution Following Autoclaving

A Rapid and Specific Method for Measuring Chloramphenicol Degradation in Aqueous Solution Following Autoclaving

An HPLC Method is reported for the measurement of chloramphenicol and its degradation product following autoclaving. The procedure, using a reversed-phase column and potassium phosphate solution as the solvent,is shown to be suitable for monitoring chloramphenicol degradation in intrathecal injectio...

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Veröffentlicht in:Journal of chromatographic science 1981-02, Vol.19 (2), p.96-97
Hauptverfasser: Lee, M.G., Dawes, S., Mannion, P.
Format: Artikel
Sprache:eng
Schlagworte:
Chloramphenicol - analysis
Chromatography, High Pressure Liquid - methods
Drug Stability
Drug Storage
Sterilization
Temperature
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Zusammenfassung:An HPLC Method is reported for the measurement of chloramphenicol and its degradation product following autoclaving. The procedure, using a reversed-phase column and potassium phosphate solution as the solvent,is shown to be suitable for monitoring chloramphenicol degradation in intrathecal injection after sterilization.
ISSN:0021-9665
1945-239X
DOI:10.1093/chromsci/19.2.96