Chromosomal analysis of two neuroblastomas

Chromosomal analysis of two neuroblastomas

We report the results of cytogenetic analysis in two children with neuroblastoma. The analysis was performed on slides obtained from a 24-hour bone marrow (BM) culture or by a direct method of the primary tumor tissue. The structural and numeric karyotype aberrations were established, including stru...

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Veröffentlicht in:Cancer genetics and cytogenetics 1993-02, Vol.65 (2), p.167-169
Hauptverfasser: Petković, Iskra, Nakić, Melita, Cepulić, Mladen, Konja, Josip
Format: Artikel
Sprache:eng
Schlagworte:
Abdominal Neoplasms - genetics
Biological and medical sciences
Child, Preschool
chromosome 1
chromosome 5
chromosome aberrations
Chromosome Aberrations - genetics
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 5
Female
Humans
Male
man
Medical sciences
neuroblastoma
Neuroblastoma - genetics
Neurology
translocation
Translocation, Genetic - genetics
Tumors of the nervous system. Phacomatoses
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Zusammenfassung:We report the results of cytogenetic analysis in two children with neuroblastoma. The analysis was performed on slides obtained from a 24-hour bone marrow (BM) culture or by a direct method of the primary tumor tissue. The structural and numeric karyotype aberrations were established, including structural aberrations of chromosome 1. The finding of i(1q) and t(1;5)(p22;q13) is of interest because these chromosome aberrations are rare in this type of disease.
ISSN:0165-4608
1873-4456
DOI:10.1016/0165-4608(93)90228-E