ATG‐Fresenius Treatment and Low‐Dose Tacrolimus: Results of a Randomized Controlled Trial in Liver Transplantation

We report the results of a prospective randomized controlled trial in liver transplantation assessing the efficacy and safety of antithymocyte globulin (ATG‐Fresenius) plus tacrolimus monotherapy at gradually decreasing doses. Patients were randomized to either: (a) standard‐dose tacrolimus plus ste...

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Veröffentlicht in:	American journal of transplantation 2010-10, Vol.10 (10), p.2296-2304
Hauptverfasser:	Benítez, C. E., Puig‐Pey, I., López, M., Martínez‐Llordella, M., Lozano, J. J., Bohne, F., Londoño, M. C., García‐Valdecasas, J. C., Bruguera, M., Navasa, M., Rimola, A., Sánchez‐Fueyo, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antilymphocyte Serum - administration & dosage Biological and medical sciences Female Graft Rejection - epidemiology Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - adverse effects Liver Transplantation - methods Liver, biliary tract, pancreas, portal circulation, spleen Male Medical sciences Middle Aged Pharmacology. Drug treatments Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Tacrolimus - administration & dosage Tacrolimus - adverse effects Tacrolimus monotherapy tacrolimus weaning tolerance induction transplantation T‐cell depletion
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Zusammenfassung:	We report the results of a prospective randomized controlled trial in liver transplantation assessing the efficacy and safety of antithymocyte globulin (ATG‐Fresenius) plus tacrolimus monotherapy at gradually decreasing doses. Patients were randomized to either: (a) standard‐dose tacrolimus plus steroids;or (b) peritransplant ATG‐Fresenius plus reduced‐dose tacrolimus monotherapy followed by weaning of tacrolimus starting 3 months after transplantation. The primary end‐point was the achievement of very low‐dose tacrolimus (every‐other‐day or once daily dose with
ISSN:	1600-6135 1600-6143
DOI:	10.1111/j.1600-6143.2010.03164.x