Cells in Stress: Transcriptional Activation of Heat Shock Genes

Cells exposed to stress, such as high temperatures, go through a series of steps that ensure the survival of the cell. When exposed to heat shock, the stressed cell assembles into a trimer, engages in binding activity and becomes phospphorylated.

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Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1993-03, Vol.259 (5100), p.1409-1410
1. Verfasser:	Morimoto, Richard I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Cell physiology Cells DNA DNA - genetics DNA - metabolism DNA-Binding Proteins - metabolism Effects of physical and chemical agents Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes Heat Heat shock proteins Heat shock response Heat-Shock Proteins - genetics HeLa cells Hot Temperature Humans Lead Models, Genetic Molecular and cellular biology Molecular Sequence Data Perspective Shock heating Transcription Factors - metabolism Transcription, Genetic Trimers
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Beschreibung
Zusammenfassung:	Cells exposed to stress, such as high temperatures, go through a series of steps that ensure the survival of the cell. When exposed to heat shock, the stressed cell assembles into a trimer, engages in binding activity and becomes phospphorylated.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.8451637