Contrasting effects of various sulfhydryl reagents on the activity of lecithin: Cholesterol acyltransferase

Lecithin:cholesterol acyltransferase, E.C. 2.3.1.43, can be either stimulated or inhibited by reducing reagents containing free sulfhydryl groups. Mercaptoethanol and dithiothreitol stimulate enzyme activity while cysteine and reduced glutathione inhibit activity. The oxidizing disulfide reagent 2-p...

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Veröffentlicht in:	Biochemical and biophysical research communications 1981-01, Vol.98 (2), p.494-500
1. Verfasser:	Verdery, Roy B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cysteine - pharmacology Dithiothreitol - pharmacology Glutathione - pharmacology Humans Mercaptoethanol - pharmacology Phosphatidylcholine-Sterol O-Acyltransferase - metabolism Sulfhydryl Compounds - pharmacology
Online-Zugang:	Volltext
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Zusammenfassung:	Lecithin:cholesterol acyltransferase, E.C. 2.3.1.43, can be either stimulated or inhibited by reducing reagents containing free sulfhydryl groups. Mercaptoethanol and dithiothreitol stimulate enzyme activity while cysteine and reduced glutathione inhibit activity. The oxidizing disulfide reagent 2-pyridine disulfide has minimal effects on enzyme activity by itself but suppresses the stimulatory effect of mercaptoethanol.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(81)90867-6