Growth response to 4‐hydroxy‐l‐threonine of Escherichia coli mutants blocked in vitamin B6 biosynthesis

Mutants of Escherichia coli (pdx B and pdx C) which are blocked in the biosynthesis of pyridoxol (vitamin B6) showed a growth response to 4‐hydroxy‐l‐threonine. This observation constitutes the first direct evidence in support of the view that 4‐hydroxy‐l‐threonine is implicated in the biosynthesis...

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Veröffentlicht in:	FEBS letters 1993-03, Vol.318 (2), p.125-128
Hauptverfasser:	Drewke, Christel, Notheis, Caroline, Hansen, Ursula, Leistner, Eckhard, Hemscheidt, Thomas, Hill, Robert E., Spenser, Ian D.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Aminopropan-2,3-diol 4-Hydroxy-l-threonine Analytical, structural and metabolic biochemistry Biological and medical sciences Biosynthesis Coenzymes, vitamins Escherichia coli Escherichia coli - growth & development Escherichia coli - metabolism Fundamental and applied biological sciences. Psychology Other biological molecules Pyridoxine - biosynthesis Pyridoxol Threonine - analogs & derivatives Threonine - metabolism Vitamin B6
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Beschreibung
Zusammenfassung:	Mutants of Escherichia coli (pdx B and pdx C) which are blocked in the biosynthesis of pyridoxol (vitamin B6) showed a growth response to 4‐hydroxy‐l‐threonine. This observation constitutes the first direct evidence in support of the view that 4‐hydroxy‐l‐threonine is implicated in the biosynthesis of vitamin B6. 1‐Aminopropan‐2,3‐diol, the decarboxylation product of 4‐hydroxy‐l‐threonine, does not support the growth of these mutants. Deuterium from deuterium‐labelled 1‐aminopropan‐2,3‐diol was not incorporated into pyridoxol.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(93)80005-F