Sequence and organization of the human mitochondrial genome
The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extre...
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| Veröffentlicht in: | Nature (London) 1981-04, Vol.290 (5806), p.457-465 |
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| container_issue | 5806 |
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| container_title | Nature (London) |
| container_volume | 290 |
| creator | Anderson, S Bankier, A. T Barrell, B. G de Bruijn, M. H. L Coulson, A. R Drouin, J Eperon, I. C Nierlich, D. P Roe, B. A Sanger, F Schreier, P. H Smith, A. J. H Staden, R Young, I. G |
| description | The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome
b
and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs. |
| doi_str_mv | 10.1038/290457a0 |
| format | Article |
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b
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and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.</description><subject>Base Sequence</subject><subject>Biological Evolution</subject><subject>Codon</subject><subject>DNA Replication</subject><subject>DNA, Mitochondrial - genetics</subject><subject>Genes</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>multidisciplinary</subject><subject>Nucleic Acid Precursors - metabolism</subject><subject>Peptide Chain Initiation, Translational</subject><subject>Peptide Chain Termination, Translational</subject><subject>RNA, Ribosomal - genetics</subject><subject>RNA, Transfer - genetics</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Transcription, Genetic</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkD1PwzAURS0EKqUg8QdAmRAMgWfHjhMxoYovqRIDMEeu89ymSmywkwF-PUYpnZjecI-O3r2EnFK4ppAVN6wELqSCPTKlXOYpzwu5T6YArEihyPJDchTCBgAElXxCJpLRUmR8Sm5f8XNAqzFRtk6cXynbfKu-cTZxJunXmKyHTtmka3qn187WvlFtskLrOjwmB0a1AU-2d0beH-7f5k_p4uXxeX63SDUH2qemQAOsVjorhEGheE6ZzLTJS1kIoJyKmopsmdXAUGuKkhnFsKQ8j61URGfkYvR-eBefDX3VNUFj2yqLbgiVFDkVtCwjeDmC2rsQPJrqwzed8l8Vhep3p-pvp4iebZ3DssN6B26HifnVmIeY2BX6auMGb2PN_1znI2tVP3jcuXbAD0FHeI0</recordid><startdate>19810409</startdate><enddate>19810409</enddate><creator>Anderson, S</creator><creator>Bankier, A. 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b
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| fulltext | fulltext |
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| ispartof | Nature (London), 1981-04, Vol.290 (5806), p.457-465 |
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| language | eng |
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| subjects | Base Sequence Biological Evolution Codon DNA Replication DNA, Mitochondrial - genetics Genes Humanities and Social Sciences Humans multidisciplinary Nucleic Acid Precursors - metabolism Peptide Chain Initiation, Translational Peptide Chain Termination, Translational RNA, Ribosomal - genetics RNA, Transfer - genetics Science Science (multidisciplinary) Transcription, Genetic |
| title | Sequence and organization of the human mitochondrial genome |
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