Sequence and organization of the human mitochondrial genome

The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extre...

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Veröffentlicht in:	Nature (London) 1981-04, Vol.290 (5806), p.457-465
Hauptverfasser:	Anderson, S, Bankier, A. T, Barrell, B. G, de Bruijn, M. H. L, Coulson, A. R, Drouin, J, Eperon, I. C, Nierlich, D. P, Roe, B. A, Sanger, F, Schreier, P. H, Smith, A. J. H, Staden, R, Young, I. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological Evolution Codon DNA Replication DNA, Mitochondrial - genetics Genes Humanities and Social Sciences Humans multidisciplinary Nucleic Acid Precursors - metabolism Peptide Chain Initiation, Translational Peptide Chain Termination, Translational RNA, Ribosomal - genetics RNA, Transfer - genetics Science Science (multidisciplinary) Transcription, Genetic
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Zusammenfassung:	The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/290457a0