Cadmium-113 Nuclear Magnetic Resonance Studies of Bovine Insulin: Two-Zinc Insulin Hexamer Specifically Binds Calcium

Cadmium-113 Nuclear Magnetic Resonance Studies of Bovine Insulin: Two-Zinc Insulin Hexamer Specifically Binds Calcium

By use of cadmium-113 nuclear magnetic resonance spectroscopy, a specific calcium ion binding site has been identified in the bovine two-zinc insulin hexamer. This site is composed of six glutamyl carboxylate groups clustered in the center of the hexamer, and is distinct from the normal zinc ion bin...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1981-05, Vol.212 (4494), p.560-562
Hauptverfasser: Sudmeier, J. L., Bell, S. J., Storm, M. C., Dunn, M. F.
Format: Artikel
Sprache:eng
Schlagworte:
550201 - Biochemistry- Tracer Techniques
ANIMALS
BASIC BIOLOGICAL SCIENCES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
Binding Sites
Cadmium
CADMIUM 113
CADMIUM ISOTOPES
Calcium (Nutrient)
Calcium - metabolism
Calcium in the body
CALCIUM IONS
Carboxylates
CATTLE
CHARGED PARTICLES
Chemical equilibrium
DOMESTIC ANIMALS
EVEN-ODD NUCLEI
FOURIER TRANSFORMATION
Grants
HORMONES
INSULIN
Insulin - metabolism
INTEGRAL TRANSFORMATIONS
INTERMEDIATE MASS NUCLEI
IONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
Ligands
Macromolecular Substances
MAGNETIC RESONANCE
Magnetic Resonance Spectroscopy
MAMMALS
Metal ions
MOLECULAR STRUCTURE
NUCLEAR MAGNETIC RESONANCE
NUCLEI
PEPTIDE HORMONES
Protein Conformation
RADIOISOTOPES
RECEPTORS
RESONANCE
RUMINANTS
STABLE ISOTOPES
TRANSFORMATIONS
Ungulates
VERTEBRATES
YEARS LIVING RADIOISOTOPES
Zinc
Zinc - metabolism
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Beschreibung
Zusammenfassung:By use of cadmium-113 nuclear magnetic resonance spectroscopy, a specific calcium ion binding site has been identified in the bovine two-zinc insulin hexamer. This site is composed of six glutamyl carboxylate groups clustered in the center of the hexamer, and is distinct from the normal zinc ion binding sites.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7010607