Cardiopulmonary dysfunction produced by reoxygenation of immature hypoxemic animals supported by cardiopulmonary bypass Prevention by intravenous metabolic pretreatment

Cardiopulmonary dysfunction produced by reoxygenation of immature hypoxemic animals supported by cardiopulmonary bypass Prevention by intravenous metabolic pretreatment

This study tests the hypothesis that reoxygenation injury is produced when cardiopulmonary bypass is initiated in immature hypoxemic piglets and that it causes cardiopulmonary dysfunction that can be avoided by intravenous metabolic treatment before and during cardiopulmonary bypass. Of 18 immature...

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Veröffentlicht in:The Journal of thoracic and cardiovascular surgery 1993-03, Vol.105 (3), p.513-519
Hauptverfasser: Matheis, Georg, Tixier, Denis B., Buckberg, Gerald D., Ihnken, Kai, Morita, Kiyozo, Sherman, Michael P., Young, Helen H.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Aspartic Acid - administration & dosage
Cardiopulmonary Bypass
Catalase - administration & dosage
Drug Combinations
Glucose - administration & dosage
Glutamates - administration & dosage
Glutamic Acid
Heart - physiopathology
Hemodynamics
Hypoxia - physiopathology
Infusions, Intravenous
Insulin - administration & dosage
Lung - physiopathology
Oxygen - metabolism
Pressure
Swine
Vascular Resistance
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Zusammenfassung:This study tests the hypothesis that reoxygenation injury is produced when cardiopulmonary bypass is initiated in immature hypoxemic piglets and that it causes cardiopulmonary dysfunction that can be avoided by intravenous metabolic treatment before and during cardiopulmonary bypass. Of 18 immature Yorkshire-Duroc piglets (aged
ISSN:0022-5223
1097-685X
DOI:10.1016/S0022-5223(19)34234-5