Immunoglobulin deposits in the biliary remnants of extrahepatic biliary atresia: a study by immunoperoxidase staining in 128 infants

Bile duct remnants taken from 128 infants during surgery for extrahepatic biliary atresia were paraffin embedded prior to immunoperoxidase staining. Immunoglobulin deposits were found in 44 remnants. They were made up of IgM alone in 25 cases and of IgM and IgG in 19. Deposits were observed along th...

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Veröffentlicht in:	Histopathology 1981-03, Vol.5 (2), p.217-221
Hauptverfasser:	HADCHOUEL, M., HUGON, R. N., ODIEVRE, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	atresia bile ducts Bile Ducts - abnormalities Bile Ducts - immunology Bile Ducts - pathology Humans Immunoglobulin G - analysis Immunoglobulin M - analysis immunoglobulins immunoperoxidase Infant Infant, Newborn
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Beschreibung
Zusammenfassung:	Bile duct remnants taken from 128 infants during surgery for extrahepatic biliary atresia were paraffin embedded prior to immunoperoxidase staining. Immunoglobulin deposits were found in 44 remnants. They were made up of IgM alone in 25 cases and of IgM and IgG in 19. Deposits were observed along the basement membranes of glandular structures. These findings suggest that extrahepatic bilary atresia might be an acquired and evolving disease.
ISSN:	0309-0167 1365-2559
DOI:	10.1111/j.1365-2559.1981.tb01779.x