Pressor effect of naloxone in septic shock

Naloxone was given intravenously to thirteen patients with prolonged hypotension. Eight patients with sepsis who were not receiving corticosteroids had a 45% increase in systolic blood-pressure within minutes of receiving 0.4--1.2 mg of naloxone. The increase in blood-pressure lasted for at least 45...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Lancet (British edition) 1981-03, Vol.1 (8219), p.529-532
Hauptverfasser:	Peters, W P, Johnson, M W, Friedman, P A, Mitch, W E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Insufficiency - physiopathology Adult Aged Blood Pressure - drug effects Cardiac Output - drug effects Endorphins - antagonists & inhibitors Endorphins - physiology Female Humans Hypotension - drug therapy Hypotension - etiology Male Middle Aged Naloxone - pharmacology Naloxone - therapeutic use Shock, Septic - complications Shock, Septic - drug therapy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Naloxone was given intravenously to thirteen patients with prolonged hypotension. Eight patients with sepsis who were not receiving corticosteroids had a 45% increase in systolic blood-pressure within minutes of receiving 0.4--1.2 mg of naloxone. The increase in blood-pressure lasted for at least 45 min. In two patients a second dose, given after recurrence of hypotension, resulted in another increase in blood-pressure. Four patients with hypoadrenocorticotropism had no pressor response to naloxone. These observations suggest that endorphins may contribute to the hypotension of sepsis and that naloxone may have therapeutic value in the treatment of septic shock.
ISSN:	0140-6736