Mammalian Gonadal Determination and Gametogenesis

Although a relationship between the X and Y chromosomes and mammalian sexual development has long been recognized, a detailed understanding of this relation is still lacking. Recent advances in somatic cell genetics and recombinant DNA technology should provide the tools for solving this fundamental...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1981-03, Vol.211 (4488), p.1265-1271
Hauptverfasser:	Gordon, Jon W., Ruddle, Frank H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Chromosome Mapping Cloning, Molecular Disorders of Sex Development DNA DNA - isolation & purification DNA Restriction Enzymes Female Fertility Gametogenesis Genes Genetic loci Genetic Markers Germ cells H-Y Antigen - genetics Human X chromosome Male Mammals Mammals - genetics Mice Nucleic Acid Hybridization Oogenesis Ovary - embryology Sex Chromosomes Sex determination (Genetics) Sex Determination Analysis Sex determination, Genetic Sex Differentiation Sexual Dimorphism Spermatogenesis Testes Testis - embryology X chromosome Y chromosome
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Beschreibung
Zusammenfassung:	Although a relationship between the X and Y chromosomes and mammalian sexual development has long been recognized, a detailed understanding of this relation is still lacking. Recent advances in somatic cell genetics and recombinant DNA technology should provide the tools for solving this fundamental problem in developmental genetics.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.6259727