A negative association of schizophrenia with an allele of the HLA DQB1 gene among African-Americans

A negative association of schizophrenia with an allele of the HLA DQB1 gene among African-Americans

Using polymorphisms of the human leukocyte antigen (HLA) DQB1 gene, a case-control study was conducted in a group of patients with schizophrenia (DSM-III, n=58) and psychiatrically normal controls matched for ethnicity ( n=72), living in the same geographical area. A significant negative association...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Schizophrenia research 1993, Vol.8 (3), p.199-209
Hauptverfasser: Nimgaonkar, V.L., Ganguli, R., Rudert, W.A., Vavassori, C., Rabin, B.S., Trucco, M.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Adult and adolescent clinical studies
Alleles
Association
Autoimmune
Autoimmune Diseases - diagnosis
Autoimmune Diseases - genetics
Autoimmune Diseases - immunology
Biological and medical sciences
Black or African American
Black People - genetics
Diabetes mellitus
Diabetes Mellitus, Type 1 - diagnosis
Diabetes Mellitus, Type 1 - genetics
Diabetes Mellitus, Type 1 - immunology
Female
Genetic Markers - genetics
Genetics
HLA
HLA DQB
HLA-DQ Antigens - genetics
HLA-DQ beta-Chains
Humans
Male
Medical sciences
Middle Aged
Models, Genetic
Multigene Family - genetics
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - genetics
Schizophrenia - immunology
Schizophrenic Psychology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Using polymorphisms of the human leukocyte antigen (HLA) DQB1 gene, a case-control study was conducted in a group of patients with schizophrenia (DSM-III, n=58) and psychiatrically normal controls matched for ethnicity ( n=72), living in the same geographical area. A significant negative association of allele HLA DQB1 ∗0602 with schizophrenia was present among African-Americans (odds ratio 0.19), but could not be detected in Caucasians.
ISSN:0920-9964
1573-2509
DOI:10.1016/0920-9964(93)90018-E