Normal excretion of m-hydroxymandelic acid in hypertensive patients
o-Hydroxymandelic acid (OHMA), m-hydroxymandelic acid (MHMA) and p-hydroxymandelic acid (PHMA) were measured in the urine of 42 normotensive and 54 hypertensive patients. Patients having high urinary MHMA levels were all found to be ingesting medications containing m-synephrine (phenylephrine). Thes...
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| Veröffentlicht in: | Clinica chimica acta 1981-01, Vol.109 (2), p.125-131 |
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| container_title | Clinica chimica acta |
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| creator | Crowley, Jan R. Couch, Margaret W. Williams, Clyde M. Threatte, Rose M. Fregly, Melvin J. |
| description | o-Hydroxymandelic acid (OHMA),
m-hydroxymandelic acid (MHMA) and
p-hydroxymandelic acid (PHMA) were measured in the urine of 42 normotensive and 54 hypertensive patients. Patients having high urinary MHMA levels were all found to be ingesting medications containing
m-synephrine (phenylephrine). These patients also had high levels of urinary
m-synephrine which was excreted as the glucuronide. When patients ingesting
m-synephrine were excluded from the analysis, no significant differences were observed between the two groups for the urinary excretion of OHMA, MHMA and PHMA. |
| doi_str_mv | 10.1016/0009-8981(81)90326-0 |
| format | Article |
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m-hydroxymandelic acid (MHMA) and
p-hydroxymandelic acid (PHMA) were measured in the urine of 42 normotensive and 54 hypertensive patients. Patients having high urinary MHMA levels were all found to be ingesting medications containing
m-synephrine (phenylephrine). These patients also had high levels of urinary
m-synephrine which was excreted as the glucuronide. When patients ingesting
m-synephrine were excluded from the analysis, no significant differences were observed between the two groups for the urinary excretion of OHMA, MHMA and PHMA.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/0009-8981(81)90326-0</identifier><identifier>PMID: 7471493</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Aged ; Aging ; Diastole ; Female ; Gas Chromatography-Mass Spectrometry ; Humans ; Hydroxy Acids - urine ; Hypertension - urine ; Male ; Mandelic Acids - urine ; Middle Aged ; Phenylephrine - metabolism ; Phenylephrine - therapeutic use ; Sex Factors ; Systole</subject><ispartof>Clinica chimica acta, 1981-01, Vol.109 (2), p.125-131</ispartof><rights>1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-644fbf1a630d33af338b476ebc54038e5d5fc5584db086136b78526c8b99dbfd3</citedby><cites>FETCH-LOGICAL-c357t-644fbf1a630d33af338b476ebc54038e5d5fc5584db086136b78526c8b99dbfd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0009-8981(81)90326-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7471493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crowley, Jan R.</creatorcontrib><creatorcontrib>Couch, Margaret W.</creatorcontrib><creatorcontrib>Williams, Clyde M.</creatorcontrib><creatorcontrib>Threatte, Rose M.</creatorcontrib><creatorcontrib>Fregly, Melvin J.</creatorcontrib><title>Normal excretion of m-hydroxymandelic acid in hypertensive patients</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>o-Hydroxymandelic acid (OHMA),
m-hydroxymandelic acid (MHMA) and
p-hydroxymandelic acid (PHMA) were measured in the urine of 42 normotensive and 54 hypertensive patients. Patients having high urinary MHMA levels were all found to be ingesting medications containing
m-synephrine (phenylephrine). These patients also had high levels of urinary
m-synephrine which was excreted as the glucuronide. When patients ingesting
m-synephrine were excluded from the analysis, no significant differences were observed between the two groups for the urinary excretion of OHMA, MHMA and PHMA.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Diastole</subject><subject>Female</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Humans</subject><subject>Hydroxy Acids - urine</subject><subject>Hypertension - urine</subject><subject>Male</subject><subject>Mandelic Acids - urine</subject><subject>Middle Aged</subject><subject>Phenylephrine - metabolism</subject><subject>Phenylephrine - therapeutic use</subject><subject>Sex Factors</subject><subject>Systole</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFtLAzEQhYMotVb_gcI-iT6sJs1lkxdBijco-qLPIZdZGtlLTbal--_d2tJHYWAYzjkzzIfQJcF3BBNxjzFWuVSS3EhyqzCdihwfoTGRBc0pU9NjND5YTtFZSt_DyLAgIzQqWEGYomM0e29jbaoMNi5CF9oma8uszhe9j-2mr03joQouMy74LDTZol9C7KBJYQ3Z0nQBmi6do5PSVAku9n2Cvp6fPmev-fzj5W32OM8d5UWXC8ZKWxIjKPaUmpJSaVkhwDrOMJXAPS8d55J5i6UgVNhC8qlw0irlbenpBF3v9i5j-7OC1Ok6JAdVZRpoV0kXnCsmCBuMbGd0sU0pQqmXMdQm9ppgvWWnt2D0Fowe6o-dxkPsar9_ZWvwh9Ae1qA_7HQYnlwHiDq5AYADHyK4Tvs2_H_gF00Hffw</recordid><startdate>19810122</startdate><enddate>19810122</enddate><creator>Crowley, Jan R.</creator><creator>Couch, Margaret W.</creator><creator>Williams, Clyde M.</creator><creator>Threatte, Rose M.</creator><creator>Fregly, Melvin J.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19810122</creationdate><title>Normal excretion of m-hydroxymandelic acid in hypertensive patients</title><author>Crowley, Jan R. ; Couch, Margaret W. ; Williams, Clyde M. ; Threatte, Rose M. ; Fregly, Melvin J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-644fbf1a630d33af338b476ebc54038e5d5fc5584db086136b78526c8b99dbfd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aging</topic><topic>Diastole</topic><topic>Female</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Humans</topic><topic>Hydroxy Acids - urine</topic><topic>Hypertension - urine</topic><topic>Male</topic><topic>Mandelic Acids - urine</topic><topic>Middle Aged</topic><topic>Phenylephrine - metabolism</topic><topic>Phenylephrine - therapeutic use</topic><topic>Sex Factors</topic><topic>Systole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crowley, Jan R.</creatorcontrib><creatorcontrib>Couch, Margaret W.</creatorcontrib><creatorcontrib>Williams, Clyde M.</creatorcontrib><creatorcontrib>Threatte, Rose M.</creatorcontrib><creatorcontrib>Fregly, Melvin J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crowley, Jan R.</au><au>Couch, Margaret W.</au><au>Williams, Clyde M.</au><au>Threatte, Rose M.</au><au>Fregly, Melvin J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normal excretion of m-hydroxymandelic acid in hypertensive patients</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>1981-01-22</date><risdate>1981</risdate><volume>109</volume><issue>2</issue><spage>125</spage><epage>131</epage><pages>125-131</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>o-Hydroxymandelic acid (OHMA),
m-hydroxymandelic acid (MHMA) and
p-hydroxymandelic acid (PHMA) were measured in the urine of 42 normotensive and 54 hypertensive patients. Patients having high urinary MHMA levels were all found to be ingesting medications containing
m-synephrine (phenylephrine). These patients also had high levels of urinary
m-synephrine which was excreted as the glucuronide. When patients ingesting
m-synephrine were excluded from the analysis, no significant differences were observed between the two groups for the urinary excretion of OHMA, MHMA and PHMA.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>7471493</pmid><doi>10.1016/0009-8981(81)90326-0</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-8981 |
| ispartof | Clinica chimica acta, 1981-01, Vol.109 (2), p.125-131 |
| issn | 0009-8981 1873-3492 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75594614 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adult Aged Aging Diastole Female Gas Chromatography-Mass Spectrometry Humans Hydroxy Acids - urine Hypertension - urine Male Mandelic Acids - urine Middle Aged Phenylephrine - metabolism Phenylephrine - therapeutic use Sex Factors Systole |
| title | Normal excretion of m-hydroxymandelic acid in hypertensive patients |
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