EPOCARBAZOLINS A AND B, NOVEL 5-LIPOXYGENASE INHIBITORS: TAXONOMY, FERMENTATION, ISOLATION, STRUCTURES AND BIOLOGICAL ACTIVITIES

New 5-lipoxygenase inhibitors, designated epocarbazolins A and B, were isolated from the culture broth of Streptomyces anulatus T688-8. These compounds showed potent rat 5-lipoxygenase inhibitory activity with weak antibacterial activity. Structural studies revealed that epocarbazolins are new carba...

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Veröffentlicht in:	Journal of antibiotics 1993/01/25, Vol.46(1), pp.25-33
Hauptverfasser:	NIHEI, YOSHIMI, YAMAMOTO, HARUAKI, HASEGAWA, MASAMI, HANADA, MINORU, FUKAGAWA, YASUO, OKI, TOSHIKAZU
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Bacteria - drug effects Biological and medical sciences Carbazoles - chemistry Carbazoles - isolation & purification Carbazoles - pharmacology Cell Line Chromatography, High Pressure Liquid Fermentation Fundamental and applied biological sciences. Psychology Hydroxyeicosatetraenoic Acids - metabolism Lipoxygenase Inhibitors - chemistry Lipoxygenase Inhibitors - isolation & purification Lipoxygenase Inhibitors - pharmacology Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Microbiology Rats Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Streptomyces - chemistry Streptomyces - classification Streptomyces anulatus
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Zusammenfassung:	New 5-lipoxygenase inhibitors, designated epocarbazolins A and B, were isolated from the culture broth of Streptomyces anulatus T688-8. These compounds showed potent rat 5-lipoxygenase inhibitory activity with weak antibacterial activity. Structural studies revealed that epocarbazolins are new carbazole antibiotics having a novel substitution pattern and an epoxide in the side chain.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.46.25