2-(Aminomethyl)phenols, a new class of saluretic agents. 2. Synthesis and pharmacological properties of the 5-aza isostere of 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenol
The synthesis and biological evaluation of 4-(aminomethyl)-6-(1,1-dimethylethyl)-2-iodo-3-pyridinol dihydrochloride (7b) are described. Compound 7b proved to be highly active as a saluretic diuretic in both rats and dogs.
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| Veröffentlicht in: | Journal of medicinal chemistry 1981-01, Vol.24 (1), p.115-117 |
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| container_end_page | 117 |
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| container_issue | 1 |
| container_start_page | 115 |
| container_title | Journal of medicinal chemistry |
| container_volume | 24 |
| creator | Stokker, G. E Smith, R. L Cragoe, E. J Ludden, C. T Russo, H. F Sweet, C. S Watson, L. S |
| description | The synthesis and biological evaluation of 4-(aminomethyl)-6-(1,1-dimethylethyl)-2-iodo-3-pyridinol dihydrochloride (7b) are described. Compound 7b proved to be highly active as a saluretic diuretic in both rats and dogs. |
| doi_str_mv | 10.1021/jm00133a024 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0022-2623 |
| ispartof | Journal of medicinal chemistry, 1981-01, Vol.24 (1), p.115-117 |
| issn | 0022-2623 1520-4804 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75589243 |
| source | ACS Publications; MEDLINE |
| subjects | Animals Blood Pressure - drug effects Chemical Phenomena Chemistry Diuretics - chemical synthesis Diuretics - pharmacology Dogs Electrolytes - urine Hypertension - physiopathology Iodopyridones - chemical synthesis Iodopyridones - pharmacology Rats |
| title | 2-(Aminomethyl)phenols, a new class of saluretic agents. 2. Synthesis and pharmacological properties of the 5-aza isostere of 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenol |
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