2-(Aminomethyl)phenols, a new class of saluretic agents. 2. Synthesis and pharmacological properties of the 5-aza isostere of 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenol

The synthesis and biological evaluation of 4-(aminomethyl)-6-(1,1-dimethylethyl)-2-iodo-3-pyridinol dihydrochloride (7b) are described. Compound 7b proved to be highly active as a saluretic diuretic in both rats and dogs.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1981-01, Vol.24 (1), p.115-117
Hauptverfasser:	Stokker, G. E, Smith, R. L, Cragoe, E. J, Ludden, C. T, Russo, H. F, Sweet, C. S, Watson, L. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Chemical Phenomena Chemistry Diuretics - chemical synthesis Diuretics - pharmacology Dogs Electrolytes - urine Hypertension - physiopathology Iodopyridones - chemical synthesis Iodopyridones - pharmacology Rats
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Beschreibung
Zusammenfassung:	The synthesis and biological evaluation of 4-(aminomethyl)-6-(1,1-dimethylethyl)-2-iodo-3-pyridinol dihydrochloride (7b) are described. Compound 7b proved to be highly active as a saluretic diuretic in both rats and dogs.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00133a024