Altered Lipid Composition, Increased Lipid Peroxidation, and Altered Fluidity of the Membrane as Evidence of Platelet Damage in Preeclampsia

OBJECTIVE: METHODS:We studied 40 primigravid women at 28–32 weeksʼ gestation; 20 were preeclamptic and 20 were normotensive. After preparing platelet membranes, we extracted lipids, measured cholesterol and phospholipid concentrations, and calculated the proportion of unsaturated to saturated fatty...

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Veröffentlicht in:	Obstetrics and gynecology (New York. 1953) 1993-03, Vol.81 (3), p.337-340
Hauptverfasser:	GARZETTI, GIOELE G, TRANQUILLI, ANDREA L, CUGINI, ANNA M, MAZZANTI, LAURA, CESTER, NELVIO, ROMANINI, CARLO
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Blood Platelets - chemistry Blood Platelets - physiology Cholesterol - blood Diseases of mother, fetus and pregnancy Fatty Acids, Unsaturated - blood Female Gynecology. Andrology. Obstetrics Humans Lipid Peroxidation - physiology Lipid Peroxides - blood Medical sciences Membrane Fluidity - physiology Membrane Lipids - blood Phospholipids - blood Pre-Eclampsia - blood Pregnancy Pregnancy. Fetus. Placenta
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Zusammenfassung:	OBJECTIVE: METHODS:We studied 40 primigravid women at 28–32 weeksʼ gestation; 20 were preeclamptic and 20 were normotensive. After preparing platelet membranes, we extracted lipids, measured cholesterol and phospholipid concentrations, and calculated the proportion of unsaturated to saturated fatty acids. Lipid peroxides expressed as conjugated dienes were determined by spectrophotometry. Membrane fluidity was determined by means of fluorescent lipophilic probes. Statistical analysis was performed by the Student t test, with significance at P < .05. RESULTS: CONCLUSIONS:
ISSN:	0029-7844 1873-233X