Vasopressin Analogs that Antagonize Antidiuretic Responses by Rats to the Antidiuretic Hormone

Vasopressin Analogs that Antagonize Antidiuretic Responses by Rats to the Antidiuretic Hormone

Four new synthetic analogs of vasopressin (antidiuretic hormone) can antagonize the antidiuretic response to intravenous vasopressin in anesthetized, water-loaded rats. They also cause a diuresis resembling that of diabetes insipidus when given intraperitoneally to conscious rats. Such antagonists m...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1981-04, Vol.212 (4490), p.49-51
Hauptverfasser: Sawyer, W. H., Pang, P. K. T., Seto, J., McEnroe, M., Lammek, B., Manning, M.
Format: Artikel
Sprache:eng
Schlagworte:
Acridines
Animals
Arginine Vasopressin - analogs & derivatives
Arginine Vasopressin - chemical synthesis
Arginine Vasopressin - pharmacology
Diuresis - drug effects
Diuretics
Dosage
Eggs
Embryos
Female
Hormones
Impurities
Observational research
Osmolar Concentration
Pharmacology
Rats
Solvents
Structure-Activity Relationship
Urine
Vasopressin
Vasopressins
Vasopressins - antagonists & inhibitors
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Zusammenfassung:Four new synthetic analogs of vasopressin (antidiuretic hormone) can antagonize the antidiuretic response to intravenous vasopressin in anesthetized, water-loaded rats. They also cause a diuresis resembling that of diabetes insipidus when given intraperitoneally to conscious rats. Such antagonists may prove to be useful both pharmacologically and therapeutically.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7209515