Interleukin-2 receptor alpha chain on acute myelocytic leukemia cells is involved in cell-to-cell interactions

Leukemic cells from 21 of 197 adult patients with de novo acute myelocytic leukemia (AML) were positive for IL-2Rα chain (IL-2Rα), whereas IL-2Rβ chain (IL-2Rβ), which is responsible for IL-2 signal transduction, was not found on leukemic cells from any of these cases tested. The expression of IL-2Rα was closely associated with that of adhesion molecules CD4, CD11b and CD22, and endopeptidase CD10. None of the IL-2Rα(+) AML cells responded to recombinant human IL-2. These data suggest that IL-2Rα on AML cells may not be involved in cellular proliferation as one of growth factor receptors but may have a role in the control of cell-to-cell interactions.