GABA as the pallidothalamic neurotransmitter: implications for basal ganglia function
GABA levels, high affinity GABA uptake and glutamic acid decar☐ylase levels are reduced in rat ventroanterolateral thalamic nucleus after destruction of the entopeduncular nucleus with kainic acid. This is strong evidence that GABA is an entopedunculothalamic neurotransmitter. The striatoentopeduncu...
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| Veröffentlicht in: | Brain research 1981-02, Vol.207 (1), p.195-199 |
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| creator | Penney, John B. Young, Anne B. |
| description | GABA levels, high affinity GABA uptake and glutamic acid decar☐ylase levels are reduced in rat ventroanterolateral thalamic nucleus after destruction of the entopeduncular nucleus with kainic acid. This is strong evidence that GABA is an entopedunculothalamic neurotransmitter. The striatoentopeduncular pathway is also GABAergic. Thus the function of the corpus striatum may be to disinhibit the thalamus. |
| doi_str_mv | 10.1016/0006-8993(81)90693-4 |
| format | Article |
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This is strong evidence that GABA is an entopedunculothalamic neurotransmitter. The striatoentopeduncular pathway is also GABAergic. Thus the function of the corpus striatum may be to disinhibit the thalamus.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(81)90693-4</identifier><identifier>PMID: 6258730</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; entopeduncular nucleus ; GABA ; gamma-Aminobutyric Acid - physiology ; globus pallidus ; Globus Pallidus - physiology ; Huntington's chorea ; Motor Skills - physiology ; Neural Inhibition ; Neural Pathways - physiology ; Rats ; Synaptic Transmission ; Thalamic Nuclei - physiology</subject><ispartof>Brain research, 1981-02, Vol.207 (1), p.195-199</ispartof><rights>1981 By Elsevier/North-Holland Biomedical Press, Amsterdam</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-a9427ebffc530f3ddd354f90b858db1e3690af14c7086bd3d1ba37b557a43d2e3</citedby><cites>FETCH-LOGICAL-c469t-a9427ebffc530f3ddd354f90b858db1e3690af14c7086bd3d1ba37b557a43d2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006899381906934$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6258730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Penney, John B.</creatorcontrib><creatorcontrib>Young, Anne B.</creatorcontrib><title>GABA as the pallidothalamic neurotransmitter: implications for basal ganglia function</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>GABA levels, high affinity GABA uptake and glutamic acid decar☐ylase levels are reduced in rat ventroanterolateral thalamic nucleus after destruction of the entopeduncular nucleus with kainic acid. This is strong evidence that GABA is an entopedunculothalamic neurotransmitter. The striatoentopeduncular pathway is also GABAergic. Thus the function of the corpus striatum may be to disinhibit the thalamus.</description><subject>Animals</subject><subject>entopeduncular nucleus</subject><subject>GABA</subject><subject>gamma-Aminobutyric Acid - physiology</subject><subject>globus pallidus</subject><subject>Globus Pallidus - physiology</subject><subject>Huntington's chorea</subject><subject>Motor Skills - physiology</subject><subject>Neural Inhibition</subject><subject>Neural Pathways - physiology</subject><subject>Rats</subject><subject>Synaptic Transmission</subject><subject>Thalamic Nuclei - physiology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQhi0EolvKP6CST6g9hNqx48QckLaoXSoh9VLO1sQeg5GTLLaDxL9vtrvi2NNo9H6M5iHkgrMrzrj6xhhTVae1-NLxr5opLSp5RFa8a-tK1ZIdk9W75QP5mPPzsgqh2Sk5VXXTtYKtyMNm_X1NIdPyhHQLMQY3lSeIMARLR5zTVBKMeQilYLqmYdjGYKGEaczUT4n2kCHSRxgfYwDq59HutE_kxEPMeH6YZ-Th548_t3fV_e_Nr9v1fWWl0qUCLesWe-9tI5gXzjnRSK9Z3zWd6zkKpRl4Lm3LOtU74XgPou2bpgUpXI3ijFzue7dpepkxFzOEbDFGGHGas2mbRrW1YItR7o02TTkn9GabwgDpzXBmdjTNDpXZoTIdN_9oGrnEPh_6535A9x464Fv0m72Oy5OvAZPJNuBo0YWEthg3hf8f-AsMgoTh</recordid><startdate>19810223</startdate><enddate>19810223</enddate><creator>Penney, John B.</creator><creator>Young, Anne B.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19810223</creationdate><title>GABA as the pallidothalamic neurotransmitter: implications for basal ganglia function</title><author>Penney, John B. ; Young, Anne B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-a9427ebffc530f3ddd354f90b858db1e3690af14c7086bd3d1ba37b557a43d2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>entopeduncular nucleus</topic><topic>GABA</topic><topic>gamma-Aminobutyric Acid - physiology</topic><topic>globus pallidus</topic><topic>Globus Pallidus - physiology</topic><topic>Huntington's chorea</topic><topic>Motor Skills - physiology</topic><topic>Neural Inhibition</topic><topic>Neural Pathways - physiology</topic><topic>Rats</topic><topic>Synaptic Transmission</topic><topic>Thalamic Nuclei - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Penney, John B.</creatorcontrib><creatorcontrib>Young, Anne B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Penney, John B.</au><au>Young, Anne B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GABA as the pallidothalamic neurotransmitter: implications for basal ganglia function</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1981-02-23</date><risdate>1981</risdate><volume>207</volume><issue>1</issue><spage>195</spage><epage>199</epage><pages>195-199</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>GABA levels, high affinity GABA uptake and glutamic acid decar☐ylase levels are reduced in rat ventroanterolateral thalamic nucleus after destruction of the entopeduncular nucleus with kainic acid. This is strong evidence that GABA is an entopedunculothalamic neurotransmitter. The striatoentopeduncular pathway is also GABAergic. Thus the function of the corpus striatum may be to disinhibit the thalamus.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>6258730</pmid><doi>10.1016/0006-8993(81)90693-4</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Brain research, 1981-02, Vol.207 (1), p.195-199 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75567230 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals entopeduncular nucleus GABA gamma-Aminobutyric Acid - physiology globus pallidus Globus Pallidus - physiology Huntington's chorea Motor Skills - physiology Neural Inhibition Neural Pathways - physiology Rats Synaptic Transmission Thalamic Nuclei - physiology |
| title | GABA as the pallidothalamic neurotransmitter: implications for basal ganglia function |
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