GABA as the pallidothalamic neurotransmitter: implications for basal ganglia function

GABA as the pallidothalamic neurotransmitter: implications for basal ganglia function

GABA levels, high affinity GABA uptake and glutamic acid decar☐ylase levels are reduced in rat ventroanterolateral thalamic nucleus after destruction of the entopeduncular nucleus with kainic acid. This is strong evidence that GABA is an entopedunculothalamic neurotransmitter. The striatoentopeduncu...

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Veröffentlicht in:Brain research 1981-02, Vol.207 (1), p.195-199
Hauptverfasser: Penney, John B., Young, Anne B.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
entopeduncular nucleus
GABA
gamma-Aminobutyric Acid - physiology
globus pallidus
Globus Pallidus - physiology
Huntington's chorea
Motor Skills - physiology
Neural Inhibition
Neural Pathways - physiology
Rats
Synaptic Transmission
Thalamic Nuclei - physiology
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Zusammenfassung:GABA levels, high affinity GABA uptake and glutamic acid decar☐ylase levels are reduced in rat ventroanterolateral thalamic nucleus after destruction of the entopeduncular nucleus with kainic acid. This is strong evidence that GABA is an entopedunculothalamic neurotransmitter. The striatoentopeduncular pathway is also GABAergic. Thus the function of the corpus striatum may be to disinhibit the thalamus.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(81)90693-4