Effect of anticardiolipin antibody in patients with recurrent fetal loss on thrombomodulin-dependent protein C activation

In order to approach an understanding of the mechanisms of fetal death in patients with antiphospholipid syndrome we investigated the association between protein C activity and anticardiolipin antibody. Protein C activity in vivo was decreased in some patients with recurrent fetal loss and a high AC...

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Veröffentlicht in:	Journal of clinical laboratory analysis 1993, Vol.7 (1), p.57-59
Hauptverfasser:	Toyoshima, Kiwamu, Makino, Tsunehisa, Ozawa, Nobuaki, Umeuchi, Masakatsu, Nozawa, Shiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion, Habitual - blood Abortion, Habitual - immunology Antibodies, Anticardiolipin - blood anticardiolipin antibody Female fetal death habitual abortion Humans Immunoglobulin G - blood In Vitro Techniques Pregnancy protein C Protein C - metabolism Receptors, Cell Surface - metabolism Receptors, Thrombin thrombomodulin
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Zusammenfassung:	In order to approach an understanding of the mechanisms of fetal death in patients with antiphospholipid syndrome we investigated the association between protein C activity and anticardiolipin antibody. Protein C activity in vivo was decreased in some patients with recurrent fetal loss and a high ACA titer. This study suggests that anticardiolipin antibody in patients with recurrent fetal loss may inhibit activation of protein C by thrombomodulin. © 1993 Wiley‐Liss, Inc.
ISSN:	0887-8013 1098-2825
DOI:	10.1002/jcla.1860070110