t(5;12)(q31;p12) A clinical entity with features of both myeloid leukemia and chronic myelomonocytic leukemia

We report two patients with a myeloproliferative disorder (Philadelphia chromosome-negative chronic myeloid leukemia) and t(5;12)(q31;p12). Until now, only three cases of a translocation (5;12)(q31;p12) have been reported. All investigators had problems classifying their patient's disease into...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1993, Vol.65 (1), p.7-11
Hauptverfasser:	Wessels, J.W., Fibbe, W.E., van der Keur, D., Landegent, J.E., van der Plas, D.C., den Ottolander, G.J., Roozendaal, K.J., Beverstock, G.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Blotting, Southern chromosome 12 chromosome 5 Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 5 chronic myeloid leukemia chronic myelomonocytic leukemia Humans Karyotyping Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative - genetics Leukemia, Myelomonocytic, Chronic - genetics Male man Middle Aged translocation Translocation, Genetic
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Zusammenfassung:	We report two patients with a myeloproliferative disorder (Philadelphia chromosome-negative chronic myeloid leukemia) and t(5;12)(q31;p12). Until now, only three cases of a translocation (5;12)(q31;p12) have been reported. All investigators had problems classifying their patient's disease into one of the well-defined entities of either MPD or myelodysplastic disorders. We postulate that this translocation may represent a subgroup of patients with features of both chronic myeloid leukemia and chronic myelomonocytic leukemia (CMMoL).
ISSN:	0165-4608 1873-4456
DOI:	10.1016/0165-4608(93)90051-M