Inflammatory peptide in spinal cord: Evidence that the mediator of antidromic vasodilatation is not substance P

Extracts from rat and bovine spinal cord were found to have 300–1000 times more cutaneous oedema-inducing activity than could be attributed to their substance P-like activity estimated by assay on guinea-pig ileum. The activity on both assay systems was reduced in cord extracts from rats pretreated...

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Veröffentlicht in:	Neuroscience letters 1980-05, Vol.18 (1), p.99-103
Hauptverfasser:	Chahl, Loris A., Manley, Simon W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Afferent Pathways - physiology Animals Animals, Newborn Biological Assay Capsaicin - pharmacology Cattle Edema Guinea Pigs Ileum - drug effects Peptides - isolation & purification Peptides - pharmacology Rats Spinal Cord - drug effects Spinal Cord - physiology Substance P - pharmacology Substance P - physiology Vasodilation
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Zusammenfassung:	Extracts from rat and bovine spinal cord were found to have 300–1000 times more cutaneous oedema-inducing activity than could be attributed to their substance P-like activity estimated by assay on guinea-pig ileum. The activity on both assay systems was reduced in cord extracts from rats pretreated as neonates with capsaicin. Results of assays of fractions obtained from gel-filtration chromatography indicated that an agent, in the molecular size range for peptides, was present in spinal cord extracts, which possessed some of the properties of substance P but was not identical to it.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(80)90219-0