Extramammary Paget Disease of Scrotum With Oncocytic Changes

We report an unusual case of primary scrotal extramammary Paget disease that infiltrated reticular dermis and lymph vessels, with metastasis in inguinal lymph node. The 67-year-old patient died at 14 months due to systemic metastases. The tumor, which was located in epidermis and infiltrated the der...

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Veröffentlicht in:	The American journal of dermatopathology 2010-10, Vol.32 (7), p.723-726
Hauptverfasser:	ANEIROS-FERNANDEZ, J, ARIAS-SANTIAGO, S, HUSEIN-ELAHMED, H, NICOLAE, Alina, O'VALLE RAVASSA, F, SERRANO-ORTEGA, S, NOGALES FERNANDEZ, F, ANEIROS CACHAZA, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Dermatology Diseases of the osteoarticular system Fatal Outcome Genital Neoplasms, Male - metabolism Genital Neoplasms, Male - pathology Humans Immunohistochemistry Male Medical sciences Osteoporosis. Osteomalacia. Paget disease Paget Disease, Extramammary - metabolism Paget Disease, Extramammary - pathology Scrotum - metabolism Scrotum - pathology Skin Neoplasms - metabolism Skin Neoplasms - pathology
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Zusammenfassung:	We report an unusual case of primary scrotal extramammary Paget disease that infiltrated reticular dermis and lymph vessels, with metastasis in inguinal lymph node. The 67-year-old patient died at 14 months due to systemic metastases. The tumor, which was located in epidermis and infiltrated the dermis, comprised cells with wide, granular, and eosinophilic cytoplasm and intense positivity for antimitochondrial antibody. This seems to be the first report of oncocytic changes in extramammary Paget disease.
ISSN:	0193-1091 1533-0311
DOI:	10.1097/DAD.0b013e3181d29de3